dc.contributor.author | Şensoy, Demet | |
dc.contributor.author | Oenal, A. | |
dc.contributor.author | Sagirli, O. | |
dc.contributor.author | Toker, S. E. | |
dc.date.accessioned | 2021-03-04T14:56:14Z | |
dc.date.available | 2021-03-04T14:56:14Z | |
dc.identifier.citation | Sagirli O., Oenal A., Toker S. E. , Şensoy D., "Simultaneous HPLC analysis of olmesartan and hydrochlorothiazide in combined tablets and in vitro dissolution studies", CHROMATOGRAPHIA, cilt.66, ss.213-218, 2007 | |
dc.identifier.issn | 0009-5893 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_84248a83-e5b4-429a-8204-8a993458d4c6 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/89904 | |
dc.identifier.uri | https://doi.org/10.1365/s10337-007-0304-9 | |
dc.description.abstract | A simple, rapid and reproducible HPLC method was developed and validated for the simultaneous determination of olmesartan (OLM) medoxomil and hydrochlorothiazide (HCT) in combined tablets. Chromatography was carried outon a 4.6 mm LD x 200 mm, 5 pm cyanocolumn with methanol-10 mM phosphoric acid containing 0.1 % triethylamine (pH 2.5, 50:50 v/v) at a flow rate of 1.0 mL min(-1) and UV detector was set at 260 nm. Valsartan (VAL) was used as internal standard (IS). A linear response was observed in the range of 0.2-6 mu g mL(-1) (r(2) = 0.9998) for OLM and 0.1-4 pg mL(-1) (r(2) = 0.9999) for HCT, respectively. The method showed good recoveries (99.56% for OLM and 99.48% for HCT) and the relative standard deviation (RSD) values for intra- and inter-day precision were 0.70-1.59 and 0.80-2.00% for OLM and 1.20-1.37 and 1.63-1.93% for HCT, respectively. The developed method was applied successfully for quality control assay of OLM and HCT in combined tablets and in vitro dissolution studies. | |
dc.language.iso | eng | |
dc.subject | Analitik Kimya | |
dc.subject | Temel Bilimler | |
dc.subject | BİYOKİMYASAL ARAŞTIRMA YÖNTEMLERİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | KİMYA, ANALİTİK | |
dc.subject | Kimya | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.title | Simultaneous HPLC analysis of olmesartan and hydrochlorothiazide in combined tablets and in vitro dissolution studies | |
dc.type | Makale | |
dc.relation.journal | CHROMATOGRAPHIA | |
dc.contributor.department | , , | |
dc.identifier.volume | 66 | |
dc.identifier.startpage | 213 | |
dc.identifier.endpage | 218 | |
dc.contributor.firstauthorID | 52596 | |