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dc.contributor.authorGüler, Erkan
dc.contributor.authorKucukhuseyin, Özlem
dc.contributor.authorOztop, Ozge
dc.contributor.authorSaglam, Esra Kaytan
dc.contributor.authorTuna, Gulay
dc.contributor.authorTuran, Saime
dc.contributor.authorYaylim, Ilhan
dc.contributor.authorCacina, Canan
dc.contributor.authorKorkmaz, Gurbet
dc.contributor.authorArıkan, Soykan
dc.date.accessioned2021-03-04T14:48:44Z
dc.date.available2021-03-04T14:48:44Z
dc.date.issued2013
dc.identifier.citationTuna G., Kucukhuseyin Ö., Arıkan S., Saglam E. K. , Güler E., Cacina C., Oztop O., Turan S., Korkmaz G., Yaylim I., "Do CDKN2 p16 540 C > G, CDKN2 p16 580 C > T, and MDM2 SNP309 T > G Gene Variants Act on Colorectal Cancer Development or Progression?", DNA AND CELL BIOLOGY, cilt.32, sa.7, ss.400-408, 2013
dc.identifier.issn1044-5498
dc.identifier.otherav_837794c0-aaf9-49e5-b742-b0bc2721695b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/89488
dc.identifier.urihttps://doi.org/10.1089/dna.2012.1933
dc.description.abstractCDNK2 p16 plays a pivotal role in G1/S transition by regulating the p53 pathway, which was regulated by a nuclear oncoprotein, mouse double minute 2 (MDM2). Overexpression of the MDM2 gene has been shown in a number of tumor types, its gene amplification is found to associate with accelerated tumor development and failure to treatment in both hereditary and sporadic cancers. Although genetic association studies have revealed the relationship between certain genetic polymorphisms and genes that play important roles in the development and progression of colorectal cancer (CRC), it is still unknown. Therefore, the polymorphisms of p16 540 C>G, 580 C>T, and MDM2 SNP309 T>G designed to investigate the risk of CRC development and progression in a Turkish population. We enrolled 87 patients with CRC and 75 healthy controls into the study. Genotypings were determined using polymerase chain reaction-restriction fragment length polymorphism techniques. Genotype distributions of p16 540 C>G and 580 C>T were found in agreement with the Hardy-Weinberg equilibrium in patients and controls. MDM2 SNP309 T>G was found in agreement with the Hardy-Weinberg equilibrium in controls, but not in patients. The results of our study, the G allele of p16 540 C>G and GG genotype of MDM2 SNP309 T>G were found significantly lower in patients compared with controls (pG and 580 C>T variants together indicate a risk haplotype for the patient group; besides, carrying the G allele of p16 540 and G allele of MDM2 also seems a risk haplotype for the patient group. Our study is the first study that investigates the relationship among variants of CDKN2 p16 540 C>G, 580 C>T, and MDM2 SNP309 T>G risk of CRC and the development and progression in the Turkish population.
dc.language.isoeng
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.subjectGenetics (clinical)
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectTemel Bilimler
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectGENETİK VE HAYAT
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectGenetics
dc.subjectClinical Biochemistry
dc.subjectCell Biology
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.titleDo CDKN2 p16 540 C > G, CDKN2 p16 580 C > T, and MDM2 SNP309 T > G Gene Variants Act on Colorectal Cancer Development or Progression?
dc.typeMakale
dc.relation.journalDNA AND CELL BIOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume32
dc.identifier.issue7
dc.identifier.startpage400
dc.identifier.endpage408
dc.contributor.firstauthorID64179


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