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Chronic mild stress-induced anhedonia in rats is coupled with the upregulation of inflammasome sensors: a possible involvement of NLRP1

dc.contributor.authorOzkartal, Ceren Sahin
dc.contributor.authorKucukali, Cem Ismail
dc.contributor.authorARICIOĞLU, FEYZA
dc.contributor.authorTuzun, Erdem
dc.date.accessioned2021-03-04T14:45:58Z
dc.date.available2021-03-04T14:45:58Z
dc.date.issued2018
dc.identifier.citationOzkartal C. S. , ARICIOĞLU F., Tuzun E., Kucukali C. I. , "Chronic mild stress-induced anhedonia in rats is coupled with the upregulation of inflammasome sensors: a possible involvement of NLRP1", PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, cilt.28, sa.3, ss.236-244, 2018
dc.identifier.issn2475-0573
dc.identifier.otherav_83387df7-f00d-4663-9e44-3f7fb6a5cc8b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/89327
dc.identifier.urihttps://doi.org/10.1080/24750573.2018.1426694
dc.description.abstractINTRODUCTION: NOD-like receptors containing pyrin domain (NLRP) are cytosolic receptors belong to innate immune system and function as sensing bodies for danger signals by forming inflammasome complex which in turn produces caspase-1-mediated interleukin (IL)-1 beta and IL-18 proinflammatory cytokines. Latest findings indicate that NLRP3 inflammasome mainly located in microglia cells in central nervous system (CNS) is linked to depression pathophysiology. However, another important CNS inflammasome, the neuronal NLRP1 inflammasome, has not been addressed in psychological stress or depression, yet. Therefore, the aim of the present study was to investigate the possible involvement NLRP1 inflammasome together with NLRP3 in chronic unpredictable mild stress (CUMS), a well-validated animal model of depression in rats.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectKlinik Tıp (MED)
dc.subjectPsikiyatri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleChronic mild stress-induced anhedonia in rats is coupled with the upregulation of inflammasome sensors: a possible involvement of NLRP1
dc.typeMakale
dc.relation.journalPSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
dc.contributor.departmentİstanbul Üniversitesi , Deneysel Tıp Araştırma Enstitüsü , Sinirbilim Ad
dc.identifier.volume28
dc.identifier.issue3
dc.identifier.startpage236
dc.identifier.endpage244
dc.contributor.firstauthorID249158


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