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Inhibition of focal adhesion kinase with her-2 targeted antibody pertuzumab (Omnitarg (R), 2C4) in breast cancer cells

dc.contributor.authorBozkurt, Betul
dc.contributor.authorKarabeyoglu, Melih
dc.contributor.authorÜNAL, BÜLENT
dc.contributor.authorYildirim, Osman
dc.contributor.authorCengiz, Omer
dc.contributor.authorYULUĞ, IŞIK
dc.contributor.authorCanbay, Emel
dc.contributor.authorGur-Dedeoglu, Bala
dc.date.accessioned2021-03-04T14:38:23Z
dc.date.available2021-03-04T14:38:23Z
dc.identifier.citationCanbay E., Gur-Dedeoglu B., Bozkurt B., Karabeyoglu M., ÜNAL B., Yildirim O., Cengiz O., YULUĞ I., "Inhibition of focal adhesion kinase with her-2 targeted antibody pertuzumab (Omnitarg (R), 2C4) in breast cancer cells", GENE THERAPY AND MOLECULAR BIOLOGY, ss.293-299, 2008
dc.identifier.issn1529-9120
dc.identifier.othervv_1032021
dc.identifier.otherav_829a6b3e-4fe0-404a-a9cf-cbaf8c552801
dc.identifier.urihttp://hdl.handle.net/20.500.12627/88953
dc.description.abstractPertuzumab (Omnitarg (R), 2C4) is a recombinant humanized monoclonal antibody targeted to extracellular region of HER-2. Previous results proved the inhibitory effect of Pertuzumab on the survival of breast cancer cells via MAPK and AM pathway. Focal adhesion kinase (FAK) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis. Here, we aimed to investigate the effects of Pertuzumab on ligand activated total FAK expression and phosphorylation in the HER-2 overexpressing BT-474 breast cancer cell line. Heregulin,vas used for ligand activation. We have found that FAK expression and phosphorylation were inhibited in with Pertuzumab in breast cancer cells.
dc.language.isoeng
dc.subjectBiyoteknoloji
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMikrobiyoloji
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.titleInhibition of focal adhesion kinase with her-2 targeted antibody pertuzumab (Omnitarg (R), 2C4) in breast cancer cells
dc.typeMakale
dc.relation.journalGENE THERAPY AND MOLECULAR BIOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.startpage293
dc.identifier.endpage299
dc.contributor.firstauthorID186263


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