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dc.contributor.authorBilge, Hatice Bilge
dc.contributor.authorSomer, A
dc.contributor.authorGuler, N
dc.contributor.authorPalanduz, S
dc.contributor.authorPalanduz, A
dc.contributor.authorYalcin, I
dc.contributor.authorOnes, U
dc.contributor.authorUstek, D
dc.contributor.authorOzturk, S
dc.contributor.authorSalman, N
dc.date.accessioned2021-03-04T14:35:21Z
dc.date.available2021-03-04T14:35:21Z
dc.date.issued1998
dc.identifier.citationPalanduz S., Palanduz A., Yalcin I., Somer A., Ones U., Ustek D., Ozturk S., Salman N., Guler N., Bilge H. B. , "In vitro chromosomal radiosensitivity in common variable immune deficiency", CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, cilt.86, sa.2, ss.180-182, 1998
dc.identifier.issn0090-1229
dc.identifier.otherav_826120dc-7e8d-4c58-9771-8b132c881a23
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/88796
dc.identifier.urihttps://doi.org/10.1006/clin.1997.4478
dc.description.abstractCommon variable immune deficiency (CVID) is characterized by low immunoglobulin levels and recurrent infections in patients with a period of normal immune function several gears after birth, It is associated with diarrhea, malabsorption, bronchiectasis, and lymphoreticular malignancies, Radiation-induced chromosome instability mag contribute to the high degree of susceptibility to neoplasia. Peripheral blood lymphocyte cultures were obtained from six patients with CVID and the healthy control group matched by age and sex, The groups did not differ in the frequency of spontaneous chromosome aberrations. After exposure to X-ray radiation, mitotic indices were found to be significantly low and incidence of chromosomal alterations were high in the CVID group. We conclude that chromosomes: of cells from patients with CVID are significantly more. radiosensitive than those of controls, Thus these patients must be protected from unnecessary X-ray examinations and in case of radiosensitive tumour, the dose of irradiation should be carefully monitored. (C) 1998 Academic Press.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectBiyokimya
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyoloji ve Biyokimya
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPATOLOJİ
dc.subjectPatoloji
dc.subjectCerrahi Tıp Bilimleri
dc.titleIn vitro chromosomal radiosensitivity in common variable immune deficiency
dc.typeMakale
dc.relation.journalCLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
dc.contributor.department, ,
dc.identifier.volume86
dc.identifier.issue2
dc.identifier.startpage180
dc.identifier.endpage182
dc.contributor.firstauthorID26826


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