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dc.contributor.authorOzel, Mavi Deniz
dc.contributor.authorIdrisoglu, Halil Atilla
dc.contributor.authorİŞLEK, EYLÜL ECE
dc.contributor.authorSAZCI, ALİ
dc.contributor.authorSonmez, Ezgi
dc.date.accessioned2021-03-04T14:07:29Z
dc.date.available2021-03-04T14:07:29Z
dc.date.issued2015
dc.identifier.citationSonmez E., Ozel M. D. , İŞLEK E. E. , SAZCI A., Idrisoglu H. A. , "Association of rs62063857 Variant of the Saitohin Gene with Parkinson's Disease", CELLULAR AND MOLECULAR NEUROBIOLOGY, cilt.35, sa.1, ss.115-121, 2015
dc.identifier.issn0272-4340
dc.identifier.othervv_1032021
dc.identifier.otherav_7fe65a14-f834-4700-8b37-26919f2d5352
dc.identifier.urihttp://hdl.handle.net/20.500.12627/87272
dc.identifier.urihttps://doi.org/10.1007/s10571-014-0102-5
dc.description.abstractSaitohin gene found within the tau gene is thought to play a role in the pathogenesis of neurodegenerative diseases. The rs62063857 polymorphism originally found in the saitohin gene seems to be the responsible SNP in this event. This polymorphism is studied mostly in patients with Alzheimer's disease. Data on Parkinson's disease are scarce. Therefore, we examined the rs62063857 polymorphism in 583 Parkinson's disease patients (347 male and 236 female) and 396 healthy controls (238 male and 158 female) by a polymerase chain reaction and restriction fragment length polymorphism method to see whether it was associated with Parkinson's disease from the City of Istanbul, Turkey. The G allele frequency was 22 % in overall controls and 16 % in Parkinson's disease patients. In this study, the saitohin rs62063857 polymorphism was associated with Parkinson's disease (chi 2 = 16.765; P = 0.000). Individuals with the AA genotype showed 1.7-fold increased risk for Parkinson's disease (chi 2 = 16.680; P = 0.000), whereas individuals with the AG genotype revealed protection against Parkinson's disease (chi 2 = 14.554; P = 0.000). After the stratification analysis according to gender, both male and female PD patients showed association with the alleles and genotypes of the rs62063857 polymorphism of the saitohin gene (chi 2 = 9.476, P = 0.009; chi 2 = 7.593, P = 0.022, respectively). When the Parkinson's patients were divided into two groups with regard to onset of the disease, both groups showed association with the disease. The Parkinson's patients with disease onset below 65 years of age showed 1.8-fold increased risk for the disease. The Parkinson's patients with disease onset over 65 showed more robust association with a 2.051-fold increased risk for the disease. Consequently, the rs62063857 polymorphism of the saitohin gene is a genetic risk factor for Parkinson's disease. Hence, this polymorphism may play a role in the etiology of Parkinson's disease.
dc.language.isoeng
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectHÜCRE BİYOLOJİSİ
dc.titleAssociation of rs62063857 Variant of the Saitohin Gene with Parkinson's Disease
dc.typeMakale
dc.relation.journalCELLULAR AND MOLECULAR NEUROBIOLOGY
dc.contributor.departmentKocaeli Üniversitesi , ,
dc.identifier.volume35
dc.identifier.issue1
dc.identifier.startpage115
dc.identifier.endpage121
dc.contributor.firstauthorID219648


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