Show simple item record

THE CLASTOGENIC EFFECT OF PYRIMETHAMINE (DARAPRIM) ON HUMAN-CHROMOSOMES IN LYMPHOCYTE-CULTURES

dc.contributor.authorEGELI, U
dc.contributor.authorERDOGAN, G
dc.date.accessioned2021-03-04T14:00:59Z
dc.date.available2021-03-04T14:00:59Z
dc.date.issued1991
dc.identifier.citationEGELI U., ERDOGAN G., "THE CLASTOGENIC EFFECT OF PYRIMETHAMINE (DARAPRIM) ON HUMAN-CHROMOSOMES IN LYMPHOCYTE-CULTURES", CELL BIOLOGY AND TOXICOLOGY, cilt.7, sa.4, ss.347-356, 1991
dc.identifier.issn0742-2091
dc.identifier.otherav_7f526582-6854-4f7b-a88f-17fe6a6b726a
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/86902
dc.identifier.urihttps://doi.org/10.1007/bf00124070
dc.description.abstractIn this study the clastogenic effect of pyrimethamine (Daraprim), a folic acid antagonist used for the treatment of toxoplasmosis and malaria on human chromosomes, was investigated. Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0.05 (normal therapeutic dose), 0.1, 0.2, 0.4, 0.8, and 1.6 mg/ml. No proliferation was observed in any of the cultures containing 1.6 mg/ml pyrimethamine. The results of the cytogenetic evaluations show that the frequency of breaks and gaps increase significantly in dose-dependent manner. Thus, pyrimethamine has a clastogenic effect on human chromosomes.
dc.language.isoeng
dc.subjectHistoloji-Embriyoloji
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectTıp
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTOKSİKOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectHÜCRE BİYOLOJİSİ
dc.titleTHE CLASTOGENIC EFFECT OF PYRIMETHAMINE (DARAPRIM) ON HUMAN-CHROMOSOMES IN LYMPHOCYTE-CULTURES
dc.typeMakale
dc.relation.journalCELL BIOLOGY AND TOXICOLOGY
dc.contributor.department, ,
dc.identifier.volume7
dc.identifier.issue4
dc.identifier.startpage347
dc.identifier.endpage356
dc.contributor.firstauthorID113049


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record