dc.contributor.author | Mataraci-Kara, Emel | |
dc.contributor.author | NAESENS, Lieve | |
dc.contributor.author | Kocabalkanli, Ayse | |
dc.contributor.author | Nassozi, Mebble | |
dc.contributor.author | Capan, Gultaze | |
dc.contributor.author | Cihan-Ustundag, Gökçe | |
dc.date.accessioned | 2021-03-04T13:47:04Z | |
dc.date.available | 2021-03-04T13:47:04Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Kocabalkanli A., Cihan-Ustundag G., NAESENS L., Mataraci-Kara E., Nassozi M., Capan G., "Diclofenac-Based Hydrazones and Spirothiazolidinones: Synthesis, Characterization, and Antimicrobial Properties", ARCHIV DER PHARMAZIE, cilt.350, sa.5, 2017 | |
dc.identifier.issn | 0365-6233 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_7e303eee-5ae2-4f69-80f5-2c0557a7a907 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/86188 | |
dc.identifier.uri | https://doi.org/10.1002/ardp.201700010 | |
dc.description.abstract | We report here the synthesis, structural characterization, and biological evaluation of novel diclofenac-based hydrazone (4a-f) and spirothiazolidinone (5a-f, 6a-f) derivatives designed as potential antimicrobial agents. The compounds were evaluated in vitro for their antiviral activity against a wide spectrum of DNA and RNA viruses. They were further screened in vitro against different strains of bacteria and fungi. The hydrazone derivatives, 4a and 4c-f, were found to be active against herpesviruses (HSV-1, HSV-2, and HSV-1 TK-), vaccinia virus, and Coxsackie B4 virus, with EC50 values between 6.6 mu g/mL and 14.7g/mL, and the selectivity index values were greater than 10 for 4a and 4f. The newly synthesized compounds (4-6) were inactive against the bacterial and the fungal strains tested, at levels below 2500, 1250, or 625g/mL. Interestingly, the key intermediate 3 with a free hydrazide moiety displayed antifungal properties against Candida albicans and C. parapsilosis at MIC values of 4.88 mu g/mL and 78.12g/mL, respectively. | |
dc.language.iso | eng | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Alkoloidler | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | KİMYA, MULTİDİSİPLİNER | |
dc.subject | Temel Bilimler | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Kimya | |
dc.subject | KİMYA, TIP | |
dc.subject | Sağlık Bilimleri | |
dc.title | Diclofenac-Based Hydrazones and Spirothiazolidinones: Synthesis, Characterization, and Antimicrobial Properties | |
dc.type | Makale | |
dc.relation.journal | ARCHIV DER PHARMAZIE | |
dc.contributor.department | KU Leuven , , | |
dc.identifier.volume | 350 | |
dc.identifier.issue | 5 | |
dc.contributor.firstauthorID | 84957 | |