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dc.contributor.authorGozubatik Celik, Rabia Gokcen
dc.contributor.authorOzkara, Cigdem
dc.date.accessioned2021-03-04T13:42:29Z
dc.date.available2021-03-04T13:42:29Z
dc.identifier.citationGozubatik Celik R. G. , Ozkara C., "Catamenial Epilepsy", EPILEPSI, cilt.24, ss.30-40, 2018
dc.identifier.othervv_1032021
dc.identifier.otherav_7dcf32e8-deeb-4736-aada-0ea5df3e64fd
dc.identifier.urihttp://hdl.handle.net/20.500.12627/85934
dc.identifier.urihttps://doi.org/10.14744/epilepsi.2018.25349
dc.description.abstractWhen seizures occur in clusters during certain stages of the menstrual cycle (perimenstrual and periovulatory stages), it is defined as catamenial epilepsy. The prevalence varies between 10% and 70%. There are 3 patterns of catamenial epilepsy: perimenstrual (most common), periovulatory, and seizures in the insufficient luteal phase. In the pathophysiology of this occurrence, the neuroactive properties of the reproduction-associated steroid hormones (direct membrane-associated short-term effect and intracellular receptor/genomic-related long-term effect) and their cyclic changes in serum levels play a role in the susceptibility of the epileptogenic area to neuroactive steroids. Among steroid hormones, while progesterone and neurosteroids are known as anticonvulsants, estrogen, the best known proconvulsant, has been found in recent studies to also have anticonvulsant effects related to Neuropeptide Y. Hormonal (medroxyprogesterone acetate, clomiphene, triptorelin, leuprolide, progesterone, goserelin), non-hormonal (acetazolamide, clobazam, lamotrigine, levetiracetam), and neurosteroid-based therapies (ganaxolone) are used in the treatment of catamenial epilepsy. Seizure control and menstrual cycle maintenance, measurement of the blood level of antiepileptic drugs before and after menstruation and adjustment of the drug dosage as required, intermittent benzodiazepine administration, acetazolamide, or hormonal treatments such as oral contraceptives during menstruation are among the treatment strategies for catamenial epilepsy.
dc.language.isoeng
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleCatamenial Epilepsy
dc.typeMakale
dc.relation.journalEPILEPSI
dc.contributor.departmentIstanbul Bakirkoy Mental Health & Neurology Training & Research Hospital , ,
dc.identifier.volume24
dc.identifier.startpage30
dc.identifier.endpage40
dc.contributor.firstauthorID249540


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