dc.contributor.author | Salman, Aydin | |
dc.contributor.author | Guzel, Ozlen | |
dc.date.accessioned | 2021-03-04T13:30:36Z | |
dc.date.available | 2021-03-04T13:30:36Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Guzel O., Salman A., "Synthesis, antimycobacterial and antitumor activities of new (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl N,N-disubstituted dithiocarbamate/O-alkyldithiocarbonate derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, cilt.14, sa.23, ss.7804-7815, 2006 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.other | av_7cbc1cc4-3d88-4458-afd8-7f3b0ecab973 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/85301 | |
dc.identifier.uri | https://doi.org/10.1016/j.bmc.2006.07.065 | |
dc.description.abstract | Reaction of 2-chloromethylsaccharin with substituted potassium dithiocarbamates and substituted potassium dithiocarbonates furnished (1, 1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl NN-disubstituted dithiocarbamates (4-15) and (1, 1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyI O-alkyldithiocarbonates (16-20). The new derivatives were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv. Compounds 4-13, 15, and 16-20 described herein showed moderate to good inhibitory activity. In particular, seven analogs 4, 5, 6, 13, and 7, 8, and 12 exhibited excellent MIC values of 1.56 and 0.78 mu g/mL, respectively. Compounds 4, 5, 10, 12, 13, and 16 were selected and screened for antitumor activity. Among the tested compounds, 4 and 5 were found to be cytotoxic, especially against leukemia cell lines CCRF-CEM, HL-60(TB), RPMI-8226, and SR with log(10)GI(50) values lower than -6.69, and against non-small cell lung cancer NCI-H522 cell line with log(10)GI(50) values lower than -6.31. Compound 10 was cytotoxic against leukemia cell line HL-60(TB), whereas 16 displayed favorable cytotoxicity against ovarian cancer cell line OVCAR-3 with log(10)GI(50) values of -6.31 and -7.45, respectively. (c) 2006 Elsevier Ltd. All rights reserved. | |
dc.language.iso | eng | |
dc.subject | KİMYA, TIP | |
dc.subject | Kimya | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | KİMYA, ORGANİK | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Biyoinorganik Kimya | |
dc.subject | Temel Bilimler | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Biyokimya | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.title | Synthesis, antimycobacterial and antitumor activities of new (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl N,N-disubstituted dithiocarbamate/O-alkyldithiocarbonate derivatives | |
dc.type | Makale | |
dc.relation.journal | BIOORGANIC & MEDICINAL CHEMISTRY | |
dc.contributor.department | , , | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 23 | |
dc.identifier.startpage | 7804 | |
dc.identifier.endpage | 7815 | |
dc.contributor.firstauthorID | 180484 | |