| dc.contributor.author | van Rijn, RM | |
| dc.contributor.author | Leurs, R | |
| dc.contributor.author | Bakker, RA | |
| dc.contributor.author | De Esch, IJP | |
| dc.contributor.author | Terzioglu, N | |
| dc.date.accessioned | 2021-03-04T13:29:30Z | |
| dc.date.available | 2021-03-04T13:29:30Z | |
| dc.date.issued | 2004 | |
| dc.identifier.citation | Terzioglu N., van Rijn R., Bakker R., De Esch I., Leurs R., "Snythesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H-4 receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.14, sa.21, ss.5251-5256, 2004 | |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.other | av_7ca8836e-7e3c-47b1-b84a-6fef13d556c4 | |
| dc.identifier.other | vv_1032021 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12627/85245 | |
| dc.identifier.uri | https://doi.org/10.1016/j.bmcl.2004.08.035 | |
| dc.description.abstract | We describe the structure-activity relationships for a series of ligands structurally related to the recently identified (5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone (1) as histamine H-4 receptor (H4R) antagonists. Furthermore we identified related benzimidazoles as novel lead compounds for the H4R. The ligands have been evaluated by radioligand displacement studies and functional assays for their interaction with both the human histamine H-3 and H-4 receptors and exhibit pK(i) values up to 7.5 at the human H4R. (C) 2004 Elsevier Ltd. All rights reserved. | |
| dc.language.iso | eng | |
| dc.subject | Eczacılık | |
| dc.subject | Temel Eczacılık Bilimleri | |
| dc.subject | Yaşam Bilimleri | |
| dc.subject | Biyokimya | |
| dc.subject | Biyoinorganik Kimya | |
| dc.subject | Temel Bilimler | |
| dc.subject | Yaşam Bilimleri (LIFE) | |
| dc.subject | Sağlık Bilimleri | |
| dc.subject | Farmakoloji ve Toksikoloji | |
| dc.subject | FARMAKOLOJİ VE ECZACILIK | |
| dc.subject | KİMYA, ORGANİK | |
| dc.subject | Temel Bilimler (SCI) | |
| dc.subject | Kimya | |
| dc.subject | KİMYA, TIP | |
| dc.title | Snythesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H-4 receptor antagonists | |
| dc.type | Makale | |
| dc.relation.journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | |
| dc.contributor.department | , , | |
| dc.identifier.volume | 14 | |
| dc.identifier.issue | 21 | |
| dc.identifier.startpage | 5251 | |
| dc.identifier.endpage | 5256 | |
| dc.contributor.firstauthorID | 173103 | |
