dc.contributor.author | Antozzi, C. | |
dc.contributor.author | Evoli, A. | |
dc.contributor.author | Brenner, T. | |
dc.contributor.author | Vaknin, A. | |
dc.contributor.author | Berrih-Aknin, S. | |
dc.contributor.author | Behin, A. | |
dc.contributor.author | Sharshar, T. | |
dc.contributor.author | De Baets, M. | |
dc.contributor.author | Losen, M. | |
dc.contributor.author | Martinez-Martinez, P. | |
dc.contributor.author | Kleopa, K. A. | |
dc.contributor.author | Zamba-Papanicolaou, E. | |
dc.contributor.author | Kyriakides, T. | |
dc.contributor.author | Kostera-Pruszczyk, A. | |
dc.contributor.author | Szczudlik, P. | |
dc.contributor.author | Szyluk, B. | |
dc.contributor.author | Lavrnic, D. | |
dc.contributor.author | Basta, I. | |
dc.contributor.author | Peric, S. | |
dc.contributor.author | Tallaksen, C. | |
dc.contributor.author | Maniaol, A. | |
dc.contributor.author | Pons, C. Casasnovas | |
dc.contributor.author | Pitha, J. | |
dc.contributor.author | Jakubikova, M. | |
dc.contributor.author | Hanisch, F. | |
dc.contributor.author | Tzartos, S. J. | |
dc.contributor.author | Deymeer, F. | |
dc.contributor.author | Saruhan-Direskeneli, G. | |
dc.contributor.author | Durmus, Hacer | |
dc.contributor.author | Tsonis, A. I. | |
dc.contributor.author | Zisimopoulou, P. | |
dc.contributor.author | Lazaridis, K. | |
dc.contributor.author | Tzartos, J. | |
dc.contributor.author | Matsigkou, E. | |
dc.contributor.author | Zouvelou, V. | |
dc.contributor.author | Mantegazza, R. | |
dc.contributor.author | Andreetta, F. | |
dc.date.accessioned | 2021-03-04T13:25:03Z | |
dc.date.available | 2021-03-04T13:25:03Z | |
dc.identifier.citation | Tsonis A. I. , Zisimopoulou P., Lazaridis K., Tzartos J., Matsigkou E., Zouvelou V., Mantegazza R., Antozzi C., Andreetta F., Evoli A., et al., "MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study.", Journal of neuroimmunology, cilt.284, ss.10-7, 2015 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_7c49ff84-ae79-4fd3-b5b6-cadf0c0060ae | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/85015 | |
dc.identifier.uri | https://doi.org/10.1016/j.jneuroim.2015.04.015 | |
dc.description.abstract | Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed. (C) 2015 Elsevier B.V. All rights reserved. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler | |
dc.subject | İmmünoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | NEUROSCIENCES | |
dc.subject | Sinirbilim ve Davranış | |
dc.subject | Yaşam Bilimleri | |
dc.title | MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study. | |
dc.type | Makale | |
dc.relation.journal | Journal of neuroimmunology | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 284 | |
dc.identifier.startpage | 10 | |
dc.identifier.endpage | 7 | |
dc.contributor.firstauthorID | 223413 | |