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dc.contributor.authorCakmakoglu, Bedia
dc.contributor.authorSOLMAZ, Soner
dc.contributor.authorGokbulut, Aysun Adan
dc.contributor.authorÖzdoğu, Hakan
dc.contributor.authorBOGA, Can
dc.contributor.authorKozanoglu, Ilknur
dc.contributor.authorBaran, Yusuf
dc.contributor.authorCincin, Birsu
dc.date.accessioned2021-03-04T13:16:48Z
dc.date.available2021-03-04T13:16:48Z
dc.date.issued2014
dc.identifier.citationSOLMAZ S., Gokbulut A. A. , Cincin B., Özdoğu H., BOGA C., Cakmakoglu B., Kozanoglu I., Baran Y., "Therapeutic Potential of Apigenin, a Plant Flavonoid, for Imatinib-Sensitive and Resistant Chronic Myeloid Leukemia Cells", NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, cilt.66, sa.4, ss.599-612, 2014
dc.identifier.issn0163-5581
dc.identifier.othervv_1032021
dc.identifier.otherav_7b8ed1b9-23b6-4c77-8afb-d17ae84ada0a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/84581
dc.identifier.urihttps://doi.org/10.1080/01635581.2014.894099
dc.description.abstractDespite the presence of many therapeutic regimens like imatinib and other tyrosine kinase inhibitors, the development of resistance, intolerance, and side effects makes chronic myeloid leukemia (CML) therapy challenging. Thus, there is a need to discover novel drugs for CML patients. In this study, we attempted to assess apigenin, a common plant dietary flavonoid, in terms of its cytotoxic, apoptotic, and cytostatic effects on imatinib-sensitive and resistant Philadelphia-positive CML cells. We analyzed apigenin's effects on cell proliferation, apoptosis, caspase-3 activity, loss of mitochondrial membrane potential, and cell cycle progression in K562 and K562/IMA3 cells. Furthermore, we described genes and gene networks that are modulated in CML in response to apigenin. Results of our study revealed that apigenin has cytotoxic and apoptotic effects on both cell types. We also displayed that apigenin induced G2/M arrest in K562 cells while arresting K562/IMA3 cells in S phase especially at the highest apigenin concentration. The expression analysis identified a set of genes that were regulated by apigenin in K652 and K562/IMA3 cells. Association of modulated genes with biological functional groups identified several networks affected by apigenin including cell survival, proliferation, cell death, cell cycle, and cell signalling pathways.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectBeslenme ve Dietetik
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectBESLENME VE DİYETETİK
dc.subjectTarım Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.titleTherapeutic Potential of Apigenin, a Plant Flavonoid, for Imatinib-Sensitive and Resistant Chronic Myeloid Leukemia Cells
dc.typeMakale
dc.relation.journalNUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
dc.contributor.departmentBaşkent Üniversitesi , ,
dc.identifier.volume66
dc.identifier.issue4
dc.identifier.startpage599
dc.identifier.endpage612
dc.contributor.firstauthorID69183


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