dc.contributor.author | Oguzkan-Balci, Sibel | |
dc.contributor.author | Pehlivan, Sacide | |
dc.contributor.author | Bayram, Aysen | |
dc.contributor.author | YAMAK, Birol | |
dc.contributor.author | Pehlivan, Mustafa | |
dc.contributor.author | Eksi, Fahriye | |
dc.contributor.author | Erdogan, Mustafa Bilge | |
dc.date.accessioned | 2021-03-02T20:47:17Z | |
dc.date.available | 2021-03-02T20:47:17Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Eksi F., Pehlivan S., Erdogan M. B. , Bayram A., Oguzkan-Balci S., YAMAK B., Pehlivan M., "MBL2 and MIF gene polymorphisms in cardiovascular patients with atherosclerotic lesions undergoing heart valve replacement", BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, cilt.31, sa.6, ss.1173-1177, 2017 | |
dc.identifier.issn | 1310-2818 | |
dc.identifier.other | av_03ac0397-2061-4709-a595-cb916164cdb0 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/8411 | |
dc.identifier.uri | https://doi.org/10.1080/13102818.2017.1375864 | |
dc.description.abstract | The basic underlying factor for cardiovascular diseases is atherosclerosis, which is a multifactorial disease driven by environmental and genetic factors. We aimed to study the genetic polymorphism in mannose binding lectin-2 (MBL2) and macrophage migration inhibitory factor (MIF) in the arteries of patients with atherosclerotic lesions who underwent cardiac valve replacement for cardiac valve stenosis. Thirty-five patients (38.9%) operated with coronary bypass surgery (coronary group, CG), 55 (61.1%) patients operated with aortic or mitral valve replacement (valve group, VG) and 100 healthy controls were analyzed for codon 54 A/B polymorphism in the MBL2 gene and -173G/C polymorphism in the MIF gene by using the method of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The comparison of the healthy control group with CG and VG in terms of the MBL2 genotypes revealed significantly lower AA genotype and A allele ratios. The comparison of the healthy control group with CG and VG in terms of the MIF genotypes showed significantly lower GG genotype and G allele ratios. We suggest that the lower frequency of the GG genotype/G allele of the MIF gene and of the AA genotype/A allele of the MBL2 gene may be associated with the ethiopathogenesis of CG and VG patients. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Biyoteknoloji | |
dc.subject | BİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ | |
dc.subject | Mikrobiyoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.title | MBL2 and MIF gene polymorphisms in cardiovascular patients with atherosclerotic lesions undergoing heart valve replacement | |
dc.type | Makale | |
dc.relation.journal | BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | |
dc.contributor.department | Gaziantep Üniversitesi , , | |
dc.identifier.volume | 31 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 1173 | |
dc.identifier.endpage | 1177 | |
dc.contributor.firstauthorID | 90020 | |