dc.contributor.author | Akman-Demir, G | |
dc.contributor.author | Direskeneli, H | |
dc.contributor.author | Serdaroglu, P | |
dc.contributor.author | Eraksoy, M | |
dc.contributor.author | Saruhan-Direskeneli, G | |
dc.contributor.author | Tasci, B | |
dc.date.accessioned | 2021-03-02T20:45:45Z | |
dc.date.available | 2021-03-02T20:45:45Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Tasci B., Direskeneli H., Serdaroglu P., Akman-Demir G., Eraksoy M., Saruhan-Direskeneli G., "Humoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behcet patients", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, cilt.113, sa.1, ss.100-104, 1998 | |
dc.identifier.issn | 0009-9104 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_0383d3a2-4b05-44b5-ba10-dd0db3e8bf3a | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/8315 | |
dc.identifier.uri | https://doi.org/10.1046/j.1365-2249.1998.00620.x | |
dc.description.abstract | Although systemic immune reactivity to 65-kD mycobacterial hsp65 (m-hsp65) has been shown previously in Behcet's disease (BD), local immune response was not investigated. Mie studied anti-m-hsp65 IgG, IgM and IgA antibodies in the serum and cerebrospinal fluid (CSF) of 25 ED patients with cerebral parenchymal involvement (p-NBD), seven ED patients with intracranial hypertension (ih-NBD), eight BD patients without central nervous system (CNS) involvement, 30 patients with multiple sclerosis (MS) and 24 patients with non-inflammatory CNS disorders (NIC). Significantly higher CSF IgG responses were detected in p-NBD patients (ELISA ratio 1.3 +/- 0.9) compared with NIC (0.7 +/- 0.4, P < 0.01). In p-NBD patients' IgG, IgM or IgA CSF anti-m-hsp65 positivity rate was 48% (12/25); this was significantly higher when compared with MS (3/30; P < 0.03) and NIC (3/24; P < 0.01). CSF anti-m-hsp65 IgG ratios correlated with the duration of ED (r = 0.4, P < 0.04) but not with the duration of neurological involvement. Serum IBM and IgA responses were elevated in ih-NBD, suggesting a different type of involvement than p-NBD. These results implicate an increased local humoral response to m-hsp65 in the CSF of p-NBD patients, which might be related to the pathogenesis of neurological involvement. | |
dc.language.iso | eng | |
dc.subject | İmmünoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.title | Humoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behcet patients | |
dc.type | Makale | |
dc.relation.journal | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | |
dc.contributor.department | , , | |
dc.identifier.volume | 113 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 100 | |
dc.identifier.endpage | 104 | |
dc.contributor.firstauthorID | 121106 | |