dc.contributor.author | Sever, Mehmet Sukru | |
dc.contributor.author | Oztop, Nida | |
dc.contributor.author | Celik, Dilara | |
dc.contributor.author | Yazici, Halil | |
dc.contributor.author | Ozluk, Yasemin | |
dc.contributor.author | Kilicaslan, Isin | |
dc.contributor.author | Caliskan, Yasar | |
dc.contributor.author | Aksoy, Aysun | |
dc.contributor.author | Ucar, Ayse Serra | |
dc.date.accessioned | 2021-03-04T12:39:20Z | |
dc.date.available | 2021-03-04T12:39:20Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Caliskan Y., Ozluk Y., Celik D., Oztop N., Aksoy A., Ucar A. S. , Yazici H., Kilicaslan I., Sever M. S. , "The Clinical Significance of Uric Acid and Complement Activation in the Progression of IgA Nephropathy", KIDNEY & BLOOD PRESSURE RESEARCH, cilt.41, sa.2, ss.148-157, 2016 | |
dc.identifier.issn | 1420-4096 | |
dc.identifier.other | av_78594ff3-1f09-43ec-8b98-5ca67672413d | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/82573 | |
dc.identifier.uri | https://doi.org/10.1159/000443415 | |
dc.description.abstract | Background/Aims: The aim of this study is to investigate the utility of clinical [age, gender, mean arterial pressure (MAP)] and laboratory parameters [eGFR, hemoglobin (Hgb), serum levels of creatinine, uric acid, albumin, proteinuria, hematuria] and also histopathological lesions (Oxford classification parameters, crescents, intensity and pattern of staining for C3, C1Q, IgA, IgG, IgM) as progression markers in patients with IgA Nephropathy (IgAN). Methods: A total of 111 IgAN patients with a follow-up period >1 year or who reached kidney failure [GFR category G5 chronic kidney disease (CKD)] = 50% from the baseline. Kaplan-Meier and Cox proportional hazards analyses were performed. Results: Mean followup period was 33+/-29 months. Thirty-seven (33.3%) patients progressed to kidney failure and 4 (3.6%) patients developed eGFR decline >= 50% from the baseline after a median of 23 and 65 months, respectively. In multivariate Cox regression analysis, baseline levels of Hgb (HR: 0.782, 95% CI 0.559-0.973, p=0.037), serum uric acid (HR: 1.293, 95% CI 1.0231.621, p=0.046), eGFR (HR: 0.966, 95% CI 0.947-0.984, p=0.004) and intensity of C3 staining (HR: 1.550, 95% CI 1.198-1.976, p=0.049) predicted primary endpoint. Serum uric acid level was associated independently with T score (beta=0.303, p=0.005) in patients with eGFR>30 ml/min/m(2). Conclusions: Hyperuricemia and the deposition of C3 are independent risk factors for IgAN progression. (C) 2016 The Author(s) Published by S. Karger AG, Basel | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler | |
dc.subject | FİZYOLOJİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | ÜROLOJİ VE NEFROLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | PERİFERAL VASKÜLER HASTALIĞI | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Fizyoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Nefroloji | |
dc.subject | Yaşam Bilimleri | |
dc.title | The Clinical Significance of Uric Acid and Complement Activation in the Progression of IgA Nephropathy | |
dc.type | Makale | |
dc.relation.journal | KIDNEY & BLOOD PRESSURE RESEARCH | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 41 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 148 | |
dc.identifier.endpage | 157 | |
dc.contributor.firstauthorID | 72533 | |