dc.contributor.author | Salman, Muhammad | |
dc.contributor.author | Khan, Rasool | |
dc.contributor.author | Shah, Faiza | |
dc.contributor.author | Khan, Zahid | |
dc.contributor.author | Tavman, Aydin | |
dc.date.accessioned | 2021-03-04T12:21:51Z | |
dc.date.available | 2021-03-04T12:21:51Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Khan R., Shah F., Salman M., Khan Z., Tavman A., "Synthesis, In Vitro and In Silico Antibacterial Evaluation of 4,5-Dihydro-1H-Indazoles", CHEMISTRYSELECT, cilt.2, sa.29, ss.9364-9368, 2017 | |
dc.identifier.issn | 2365-6549 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_76edb18a-dff6-4c85-a2a9-06e2270446d0 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/81648 | |
dc.identifier.uri | https://doi.org/10.1002/slct.201701244 | |
dc.description.abstract | Synthesis and evaluation of in-vitro and in-silico anti-bacterial potential of a series of 4, 5-dihydro-1H-indazoles is reported here. The synthesis of the target 4,5-dihydro-1H-indazoles was accomplished by reacting 1,5-diaryl,4-acetyl cyclohexen-3-one with hydrazine hydrate and selected hydrazides. All the synthesized compounds were evaluated for their anti-bacterial potential against Escherichia coli, Proteus vulgaris, Staphylococcus aureus and Salmonella typhimurium. Among the synthesized indazoles, N,N-dimethyl-4-(3-methyl-6-phenyl-4,5-dihydro-1H-indazol-4-yl)aniline and 3-methyl-4-(3-nitrophenyl)-1,6-diphenyl-4,5-dihydro-1H-indazole exhibited highest antimicrobial activity against Salmonella typhimurium i.e. MIC50 = 3.85 and 4.12 mg/ml respectively. Docking studies were also carried out to provide an insight into binding interaction with the active site of respective enzyme. | |
dc.language.iso | eng | |
dc.subject | Kimya | |
dc.subject | KİMYA, MULTİDİSİPLİNER | |
dc.subject | Temel Bilimler | |
dc.subject | Alkoloidler | |
dc.subject | Biyokimya | |
dc.subject | Temel Bilimler (SCI) | |
dc.title | Synthesis, In Vitro and In Silico Antibacterial Evaluation of 4,5-Dihydro-1H-Indazoles | |
dc.type | Makale | |
dc.relation.journal | CHEMISTRYSELECT | |
dc.contributor.department | University of Peshawar , , | |
dc.identifier.volume | 2 | |
dc.identifier.issue | 29 | |
dc.identifier.startpage | 9364 | |
dc.identifier.endpage | 9368 | |
dc.contributor.firstauthorID | 584972 | |