Basit öğe kaydını göster

dc.contributor.authorGorgun, Didem
dc.contributor.authorMidilli, Kenan
dc.contributor.authorSecik, Funda
dc.contributor.authorAkkaya, Vakur
dc.contributor.authorYildiz, Pinar
dc.date.accessioned2021-03-04T11:47:01Z
dc.date.available2021-03-04T11:47:01Z
dc.date.issued2013
dc.identifier.citationGorgun D., Secik F., Midilli K., Akkaya V., Yildiz P., "Diagnostic and prognostic significance of survivin levels in malignant pleural effusion", RESPIRATORY MEDICINE, cilt.107, sa.8, ss.1260-1265, 2013
dc.identifier.issn0954-6111
dc.identifier.otherav_741ca8d0-ef9a-43c4-9a10-6facd4914c2d
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/79808
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2013.04.011
dc.description.abstractWe aimed to evaluate the diagnostic and prognostic value of measuring survivin levels, which is an inhibitor of apoptosis in pleural effusions. Methods: Group I, malignant (MPE) (n = 51); Group II, tuberculosis (TPE) (n = 18); Group III transudative (TE) (n = 9) effusions were enrolled prospectively. We used ELISA to analyze 78 effusions. The value for the differential diagnosis and the correlation between survivin and survival in MPE were analyzed. Results: Survivin level was 41.75 +/- 76.20 in MPE, 15.83 +/- 10.92 in TPE and 8.33 +/- 8.67 in TE. When the patients divided two groups as malignant and non-malignant pleural effusion (non-MPE), survivin level was significantly higher in MPE (41.75 +/- 76.20) than in non-MPE (13.33 +/- 2.05) (p = 0.012). The cutoff value for survivin levels detected by ROC curve analysis was 7.5 pg/ml, with sensitivity and specificity values of 72%, 44%, respectively. Survivin had no discriminative power in differentiating exudative effusions of MPE from TPE (p = 0.405). There was no correlation between survivin level and age, sex, location, fluid pH, glucose, protein, albumine and ADA level while there was significant moderate correlation with fluid LDH (r = 0.49; p < 0.001). Survivin levels can distinguish patients who had poor prognosis (median survival 75 days, n = 24) and those who had good prognosis (median survival 219 days, n = 27, p = 0.03) in MPE.
dc.language.isoeng
dc.subjectKardiyoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectGöğüs Hastalıkları ve Allerji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectSOLUNUM SİSTEMİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCARDIAC ve CARDIOVASCULAR SİSTEMLER
dc.titleDiagnostic and prognostic significance of survivin levels in malignant pleural effusion
dc.typeMakale
dc.relation.journalRESPIRATORY MEDICINE
dc.contributor.departmentIstanbul Yedikule Chest Diseases & Thoracic Surgery Training & Research Hospital , ,
dc.identifier.volume107
dc.identifier.issue8
dc.identifier.startpage1260
dc.identifier.endpage1265
dc.contributor.firstauthorID43373


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster