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dc.contributor.authorPul, Mehmet
dc.contributor.authorGurcan, Saban
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorUzun, Hafize
dc.contributor.authorAydin, Seval
dc.contributor.authorAksu, Burhan
dc.contributor.authorInan, Mustafa
dc.contributor.authorKanter, Mehmet
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorDurmus-Altun, Gulay
dc.date.accessioned2021-03-04T11:28:43Z
dc.date.available2021-03-04T11:28:43Z
dc.date.issued2007
dc.identifier.citationAksu B., Inan M., Kanter M., Puyan F. O. , Uzun H., Durmus-Altun G., Gurcan S., Aydin S., Ayvaz S., Pul M., "The effects of methylene blue on renal scarring due to pyelonephritis in rats", PEDIATRIC NEPHROLOGY, cilt.22, sa.7, ss.992-1001, 2007
dc.identifier.issn0931-041X
dc.identifier.othervv_1032021
dc.identifier.otherav_728bb64a-b941-4b0d-a79e-a969154a4fc2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/78843
dc.identifier.urihttps://doi.org/10.1007/s00467-007-0464-8
dc.description.abstractThe aim of this study was to evaluate the efficiency of methylene blue (MB) in preventing renal scar formation after the induction of pyelonephritis (PNP) in a rat model with delayed antimicrobial therapy. An inoculum of the K-12 strain of Escherichia coli was injected into both kidneys. Control groups received isotonic saline instead of bacterial solution. Four equal groups were then formed: the PNP group was untreated and the PNP ciprofloxacin (CIP) treated group was treated only with CIP intraperitoneally (i.p.) starting on the third day following bacterial inoculation. In the PNP (MB)-treated group, MB was given i.p., and in the PNP MB + CIP-treated group, MB + CIP were administered i.p.. In the sixth week following bacterial inoculation, all rats were sacrificed, and both kidneys of the rats in all groups were examined biochemically and histopathologically for renal scarring. Renal scar was significant in the groups treated with MB alone or MB + CIP combination compared with untreated or antibiotic only groups. Delayed treatment with antibiotics had no effect on scarring. These results suggest that the addition of MB to the delayed antibiotic therapy might be beneficial in preventing PNP-induced oxidative renal tissue damage.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectPEDİATRİ
dc.titleThe effects of methylene blue on renal scarring due to pyelonephritis in rats
dc.typeMakale
dc.relation.journalPEDIATRIC NEPHROLOGY
dc.contributor.department, ,
dc.identifier.volume22
dc.identifier.issue7
dc.identifier.startpage992
dc.identifier.endpage1001
dc.contributor.firstauthorID18368


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