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Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro

dc.contributor.authorBİLALOĞLU, RAHMİ
dc.contributor.authorÇİNKILIÇ, NİLÜFER
dc.contributor.authorÇETİNTAŞ, SİBEL
dc.contributor.authorZorlu, Tolga
dc.contributor.authorVATAN, ÖZGÜR
dc.contributor.authorYILMAZ, DİLEK
dc.contributor.authorÇAVAŞ, Tolga
dc.contributor.authorTUNÇ, SEMA
dc.contributor.authorOzkan, Lutfi
dc.date.accessioned2021-03-04T11:05:38Z
dc.date.available2021-03-04T11:05:38Z
dc.identifier.citationÇİNKILIÇ N., ÇETİNTAŞ S., Zorlu T., VATAN Ö., YILMAZ D., ÇAVAŞ T., TUNÇ S., Ozkan L., BİLALOĞLU R., "Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro", FOOD AND CHEMICAL TOXICOLOGY, cilt.53, ss.359-363, 2013
dc.identifier.issn0278-6915
dc.identifier.otherav_70955076-6f14-4542-b114-59ce6af0ae7f
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/77587
dc.identifier.urihttps://doi.org/10.1016/j.fct.2012.12.008
dc.description.abstractThe present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for irradiation. The results of the alkaline comet assay revealed that quinic acid and chlorogenic acid decreased the DNA damage induced by X-ray irradiation and provided a significant radioprotective effect. Quinic acid decreased the presence of irradiation-induced DNA damage by 5.99-53.57% and chlorogenic acid by 4.49-48.15%, as determined by the alkaline comet assay. The results show that quinic acid and chlorogenic acid may act as radioprotective compounds. Future studies should focus on determining the mechanism by which these phenolic acids provide radioprotection. (c) 2012 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectTarımsal Bilimler
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectGIDA BİLİMİ VE TEKNOLOJİSİ
dc.subjectTarım Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectGıda Mühendisliği
dc.subjectZiraat
dc.subjectMühendislik ve Teknoloji
dc.titleRadioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro
dc.typeMakale
dc.relation.journalFOOD AND CHEMICAL TOXICOLOGY
dc.contributor.departmentBursa Uludağ Üniversitesi , ,
dc.identifier.volume53
dc.identifier.startpage359
dc.identifier.endpage363
dc.contributor.firstauthorID208464


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