dc.contributor.author | Dimas, Konstantinos | |
dc.contributor.author | Ikitimur, Elif Ilkay | |
dc.contributor.author | ARI, FERDA | |
dc.contributor.author | Guney, Emel | |
dc.contributor.author | YILMAZ, VEYSEL TURAN | |
dc.contributor.author | ULUKAYA, Engin | |
dc.date.accessioned | 2021-03-04T10:47:23Z | |
dc.date.available | 2021-03-04T10:47:23Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | ULUKAYA E., ARI F., Dimas K., Ikitimur E. I. , Guney E., YILMAZ V. T. , "Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.46, sa.10, ss.4957-4963, 2011 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.other | av_6ef889a0-3095-4e42-b5b3-235a3bb27cdd | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/76609 | |
dc.identifier.uri | https://doi.org/10.1016/j.ejmech.2011.07.055 | |
dc.description.abstract | Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC(50) values were 0.09 mu M for MDA-MB-231 and 3.05 mu M for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment. (C) 2011 Elsevier Masson SAS. All rights reserved. | |
dc.language.iso | eng | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Temel Bilimler | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Kimya | |
dc.subject | KİMYA, TIP | |
dc.title | Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo | |
dc.type | Makale | |
dc.relation.journal | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | |
dc.contributor.department | Bursa Uludağ Üniversitesi , Tıp Fakültesi , | |
dc.identifier.volume | 46 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 4957 | |
dc.identifier.endpage | 4963 | |
dc.contributor.firstauthorID | 202121 | |