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dc.contributor.authorSchalke, Berthold
dc.contributor.authorSaruhan-Direskeneli, Guher
dc.contributor.authorPfister, Frederick
dc.contributor.authorMelms, Arthur
dc.contributor.authorStroebel, Philipp
dc.contributor.authorMarx, Alexander
dc.date.accessioned2021-03-02T20:32:58Z
dc.date.available2021-03-02T20:32:58Z
dc.date.issued2013
dc.identifier.citationMarx A., Pfister F., Schalke B., Saruhan-Direskeneli G., Melms A., Stroebel P., "The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes", AUTOIMMUNITY REVIEWS, cilt.12, sa.9, ss.875-884, 2013
dc.identifier.issn1568-9972
dc.identifier.otherav_02873835-f5f8-42f1-bd9f-f8283c251c8f
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/7645
dc.identifier.urihttps://doi.org/10.1016/j.autrev.2013.03.007
dc.description.abstractThe thymus plays distinct roles in the pathogenesis of the different Myasthenia gravis (MG) subtypes. Inflammatory, neoplastic and age-related alterations of the thymus are of pivotal relevance for the initiation of antiacetylcholine receptor (AChR) autoimmunity in early onset MG, thymoma-associated MG and, likely, late onset MG, respectively. By contrast the thymus is presumably not related to MG that is due to autoantibodies to the muscle specific kinase, MuSK. Finally, the role of the thymus is still obscure in MG defined by antibodies against the agrin receptor LRP4 and in MG without all of the above autoantibdies (triple sero-negative MG) since these MG subtypes have been described only recently and thymectomy has not been their standard treatment This review aims to give an update on intrathymic mechanisms of tolerance breakdown in MG, including abnormal T cell selection and activation, the role of thymic myoid cells, the autoimmune regulator (AIRE) and regulatory T cells. (C) 2013 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleThe different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes
dc.typeMakale
dc.relation.journalAUTOIMMUNITY REVIEWS
dc.contributor.departmentRuprecht Karls University Heidelberg , ,
dc.identifier.volume12
dc.identifier.issue9
dc.identifier.startpage875
dc.identifier.endpage884
dc.contributor.firstauthorID210064


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