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Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats

dc.contributor.authorTahan, Veysel
dc.contributor.authorUzun, Hafize
dc.contributor.authorTarcin, Orhan
dc.contributor.authorAydogan, Fatih
dc.contributor.authorZengin, Kagan
dc.contributor.authorTahan, Gulgun
dc.contributor.authorAkin, Hakan
dc.contributor.authorRamadan, Saime Sezgin
dc.contributor.authorYapicier, Ozlem
dc.date.accessioned2021-03-04T10:06:14Z
dc.date.available2021-03-04T10:06:14Z
dc.date.issued2010
dc.identifier.citationTahan G., Akin H., Aydogan F., Ramadan S. S. , Yapicier O., Tarcin O., Uzun H., Tahan V., Zengin K., "Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats", CANADIAN JOURNAL OF SURGERY, cilt.53, sa.5, ss.313-318, 2010
dc.identifier.issn0008-428X
dc.identifier.othervv_1032021
dc.identifier.otherav_6b847d6b-842c-4d3b-a223-b8383c694272
dc.identifier.urihttp://hdl.handle.net/20.500.12627/74342
dc.description.abstractBackground: Hepatic stellate cells, the main mediators in the pathogenesis of fibrosis, are triggered by free radicals and produce collagen. Melatonin is a powerful physiologic scavenger of hydroxyl radicals. It is also involved in the inhibitory regulation of the collagen content in tissue. There is no effective treatment available for liver fibrosis. Our objective was to evaluate the effects of melatonin on liver fibrosis induced by bile-duct ligation (BDL) in rats.
dc.language.isoeng
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.titleMelatonin ameliorates liver fibrosis induced by bile-duct ligation in rats
dc.typeMakale
dc.relation.journalCANADIAN JOURNAL OF SURGERY
dc.contributor.departmentPennsylvania Commonwealth System of Higher Education (PCSHE) , ,
dc.identifier.volume53
dc.identifier.issue5
dc.identifier.startpage313
dc.identifier.endpage318
dc.contributor.firstauthorID18891


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