dc.contributor.author | Deniz, Günnur | |
dc.contributor.author | Aktas, Esin | |
dc.contributor.author | Aydogan, Metin | |
dc.contributor.author | Ozen, Ahmet | |
dc.contributor.author | AKKOÇ, TUNÇ | |
dc.contributor.author | Eifan, Aarif O. | |
dc.contributor.author | Gocmen, Izlem | |
dc.contributor.author | Bahceciler, Nerin N. | |
dc.contributor.author | Barlan, Isil | |
dc.date.accessioned | 2021-03-04T09:40:31Z | |
dc.date.available | 2021-03-04T09:40:31Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Aydogan M., Ozen A., AKKOÇ T., Eifan A. O. , Aktas E., Deniz G., Gocmen I., Bahceciler N. N. , Barlan I., "Risk factors for persistence of asthma in children: 10-year follow-up", JOURNAL OF ASTHMA, cilt.50, sa.9, ss.938-944, 2013 | |
dc.identifier.issn | 0277-0903 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_695be012-570c-406d-9377-fe9f5d1603a1 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/73010 | |
dc.identifier.uri | https://doi.org/10.3109/02770903.2013.831872 | |
dc.description.abstract | Objective: Risk factors related to the outcome of childhood asthma are not yet well established. We aimed to investigate the long-term outcome for children with asthma to determine the risk factors in predicting persistence of disease. Methods: Sixty-two children with asthma were evaluated retrospectively at the end of a 10-year follow-up. Patients were asked to complete a questionnaire requesting clinical information, and underwent physical examination, skin prick testing, a pulmonary function test and bronchial provocation testing. Immunologic parameters evaluated were allergen-specific IgE and IgG4 levels, and allergen-induced generation of CD4(+)CD25(+) cells. Results: Mean age at final assessment was 15.9 +/- 3.6 years, and duration of follow-up was 10.30 +/- 1.27 years. Fifty percent of patients outgrew their asthma during the 10-year follow-up period. All the non-atopic patients outgrew their disease during the study period, whereas 67% of atopic patients did not. We identified two risk factors independently related to the persistence of symptoms: presence of bronchial hyper-responsiveness and presence of rhinitis. Atopic children who were in remission demonstrated significantly higher allergen-induced CD4(+)CD25(+) T cells compared to healthy controls. Conclusions: Atopy, presence of rhinitis, positive and presence of bronchial hyper-reactivity are important risk factors for the persistence of asthma in children. Allergen-induced CD4(+)CD25(+) T cells were higher in the atopic children who outgrew their disease, implicating an immunological mechanism of asthma remission in children. | |
dc.language.iso | eng | |
dc.subject | SOLUNUM SİSTEMİ | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Göğüs Hastalıkları ve Allerji | |
dc.subject | Klinik Tıp | |
dc.subject | ALERJİ | |
dc.subject | Klinik Tıp (MED) | |
dc.title | Risk factors for persistence of asthma in children: 10-year follow-up | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF ASTHMA | |
dc.contributor.department | Marmara Üniversitesi , , | |
dc.identifier.volume | 50 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 938 | |
dc.identifier.endpage | 944 | |
dc.contributor.firstauthorID | 45690 | |