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dc.contributor.authorSozen, Seyma
dc.contributor.authorCacina, Canan
dc.contributor.authorYurdum, Melis
dc.contributor.authorToptas, Bahar
dc.contributor.authorAgachan, Bedia
dc.contributor.authorKARAALI, Zeynep Ermis
dc.contributor.authorGok, Ozlem
dc.date.accessioned2021-03-04T09:38:38Z
dc.date.available2021-03-04T09:38:38Z
dc.date.issued2010
dc.identifier.citationKARAALI Z. E. , Sozen S., Yurdum M., Cacina C., Toptas B., Gok O., Agachan B., "Effect of genetic variants of chemokine receptors on the development of myocardial infarction in Turkish population", MOLECULAR BIOLOGY REPORTS, cilt.37, sa.7, ss.3615-3619, 2010
dc.identifier.issn0301-4851
dc.identifier.otherav_692b21f8-ba9f-45e6-9ea2-ae1f61c432c8
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/72886
dc.identifier.urihttps://doi.org/10.1007/s11033-010-0011-8
dc.description.abstractInflammation is a crucial component of coronary atherosclerosis and myocardial infarction (MI). Chemokine receptors are important modulators of inflammation. Polymorphisms in genes coding for chemokine receptors, CCR2 and CCR5, have been studied as genetic markers of coronary artery disease. In the present study, we investigated whether genetic variants of CCR2-V64I and CCR5-delta32 chemokine receptors have any effect on the development of myocardial infarction. A total of 146 MI patients and 202 control subjects were genotyped for CCR2 and CCR5. CCR2-V64I genotypes were not significantly different between patients with MI and controls (P>0.05). CCR5-delta32 genotype distribution in cases was significantly different from that of controls (P = 0.042). The CCR5-delta32 wt/deletion genotype frequencies for controls and cases were 0.10 and 0.19, respectively and individuals with CCR5-delta32 wt/deletion genotype had a 2.13-fold increased risk of myocardial infarction (P = 0.0013). Individuals carrying the CCR5-delta32 heterozygote or homozygous variant genotype (deletion/deletion + wt/deletion) had a 1.96-fold increased risk of myocardial infarction compared with the wild-type genotype (wt/wt) (p: 0.016). In conclusion, our data have suggested that genetic variant of CCR5 might be associated with the development of MI. Further larger sample size studies are required to confirm our findings.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectSitogenetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleEffect of genetic variants of chemokine receptors on the development of myocardial infarction in Turkish population
dc.typeMakale
dc.relation.journalMOLECULAR BIOLOGY REPORTS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume37
dc.identifier.issue7
dc.identifier.startpage3615
dc.identifier.endpage3619
dc.contributor.firstauthorID69127


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