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Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice

dc.contributor.authorIraz, M
dc.contributor.authorArmutcu, FERAH
dc.contributor.authorGurel, A
dc.contributor.authorAkyol, O
dc.contributor.authorIlhan, A
dc.date.accessioned2021-03-04T09:20:31Z
dc.date.available2021-03-04T09:20:31Z
dc.date.issued2004
dc.identifier.citationIlhan A., Iraz M., Gurel A., Armutcu F., Akyol O., "Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice", NEUROCHEMICAL RESEARCH, cilt.29, sa.12, ss.2287-2292, 2004
dc.identifier.issn0364-3190
dc.identifier.otherav_67c8a622-e151-4260-a4b2-fb165af5d1ad
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/72016
dc.identifier.urihttps://doi.org/10.1007/s11064-004-7038-y
dc.description.abstractSince overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectYaşam Bilimleri
dc.subjectSinirbilim ve Davranış
dc.subjectNEUROSCIENCES
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleCaffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice
dc.typeMakale
dc.relation.journalNEUROCHEMICAL RESEARCH
dc.contributor.department, ,
dc.identifier.volume29
dc.identifier.issue12
dc.identifier.startpage2287
dc.identifier.endpage2292
dc.contributor.firstauthorID95000


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