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Effects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats

dc.contributor.authorBolkent, Sehnaz
dc.contributor.authorTunali, Sevim
dc.contributor.authorKoyuturk, MERAL
dc.contributor.authorYanardag, Refiye
dc.date.accessioned2021-03-04T09:18:04Z
dc.date.available2021-03-04T09:18:04Z
dc.date.issued2005
dc.identifier.citationKoyuturk M., Tunali S., Bolkent S., Yanardag R., "Effects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats", BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.104, sa.3, ss.233-247, 2005
dc.identifier.issn0163-4984
dc.identifier.otherav_678defcf-32ae-454a-85b1-d2e8b5429624
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/71855
dc.identifier.urihttps://doi.org/10.1385/bter:104:3:233
dc.description.abstractThe aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. Degenerative changes were observed in diabetic animals by light and transmission electron microscopes. Although there were individual differences in diabetic animals to which vanadium was given, some reduction of degenerative changes were detected. After 60 d of treatment, serum aspartate and alanine transaminase, alkaline phosphatase, blood glucose levels, liver lipid peroxidation, and nonenzymatic glycosylation significantly increased, but liver glutathione levels significantly decreased in the diabetic group. On the other hand, treatment with vanadyl sulfate reversed these effects. As a result, it might be concluded that vanadyl sulfate has a protective effect on damage of liver of streptozotocin-induced diabetic rats.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleEffects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats
dc.typeMakale
dc.relation.journalBIOLOGICAL TRACE ELEMENT RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , Mühendislik Fakültesi Kimya Bölümü , Kimya
dc.identifier.volume104
dc.identifier.issue3
dc.identifier.startpage233
dc.identifier.endpage247
dc.contributor.firstauthorID11898


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