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dc.contributor.authorGormus, Uzay
dc.contributor.authorYilmaz, HÜLYA
dc.contributor.authorİşbir, TURGAY
dc.contributor.authorErgen, Arzu
dc.contributor.authorTurna, Akif
dc.contributor.authorYaylim-Eraltan, Ilhan
dc.contributor.authorBozkurt, Nilufer
dc.date.accessioned2021-03-04T09:15:46Z
dc.date.available2021-03-04T09:15:46Z
dc.date.issued2007
dc.identifier.citationGormus U., Ergen A., Yaylim-Eraltan I., Yilmaz H., Turna A., Bozkurt N., İşbir T., "Fas-1377 A/G polymorphism in lung cancer", IN VIVO, cilt.21, sa.4, ss.663-666, 2007
dc.identifier.issn0258-851X
dc.identifier.othervv_1032021
dc.identifier.otherav_67747f5d-8d7f-422f-9b98-fc76e287bf45
dc.identifier.urihttp://hdl.handle.net/20.500.12627/71778
dc.description.abstractBackground: Reduced expression of Fas and/or increased expression of FasL is known to exist in some cancer types including lung cancer, so the Fas/FasL system may play a role in the course of cancer. Lack of cell surface Fas expression is one of the main routes of apoptotic resistance in tumor formation and progression. Functional mutations in the Fas gene that impair apoptotic signal transduction are associated with susceptibility to various types of cancer. In this study, we focused on lung cancer. Patients and Methods: The genotypic tendencies that may occur due to a specific point mutation (Fas-1377 G -> A) on promoter region for Fas were evaluated. Results: We did not find any relationship between Fas-1377 G -> A polymorphism and lung cancer. But there was a significantly higher number of A G patients who smoked than GG ones. Conclusion: There was no relationship between Fas-1377 G-A polymorphism and lung cancer, but it was statistically significant that smoking might increase the possibility of creating lung cancer in AG genotypes more than in other genotypes.
dc.language.isoeng
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.titleFas-1377 A/G polymorphism in lung cancer
dc.typeMakale
dc.relation.journalIN VIVO
dc.contributor.department, ,
dc.identifier.volume21
dc.identifier.issue4
dc.identifier.startpage663
dc.identifier.endpage666
dc.contributor.firstauthorID64094


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