dc.contributor.author | Cavusoglu, Tarik | |
dc.contributor.author | Guzel, Elif | |
dc.contributor.author | Kilic, Emine | |
dc.contributor.author | Ucgan, Duygu | |
dc.contributor.author | Piskin, Erhan | |
dc.contributor.author | AYDIN, HALİL MURAT | |
dc.contributor.author | KORKUSUZ, PETEK | |
dc.contributor.author | Vargel, Ibrahim | |
dc.date.accessioned | 2021-03-04T08:57:57Z | |
dc.date.available | 2021-03-04T08:57:57Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | AYDIN H. M. , KORKUSUZ P., Vargel I., Kilic E., Guzel E., Cavusoglu T., Ucgan D., Piskin E., "A 6-month in vivo study of polymer/mesenchymal stem cell constructs for cranial defects", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, cilt.26, sa.2, ss.207-221, 2011 | |
dc.identifier.issn | 0883-9115 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_65f86476-53b7-4f7e-b809-8538531690b9 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/70841 | |
dc.identifier.uri | https://doi.org/10.1177/0883911511399411 | |
dc.description.abstract | Two biodegradable polymers, poly(L-lactide) and poly(epsilon-caprolactone) were blended (50/50) and used to produce polymeric scaffolds by the dual porogen approach using a salt leaching technique to create pores within the matrix, while supercritical-CO2 treatment was used to enhance the interconnectivity and to remove impurities from synthesis steps. The scaffolds were highly porous (porosity >90%) with interconnected pore morphologies. These biodegradable scaffolds were evaluated in Sprague Dawley rats for osteoconductive properties over a 6-month period. Bone specimens were analyzed after 1, 3, and 6 months, for bone healing and tissue response. The cortical bone remodeling by controlled osteoblastic and osteoclastic activities as well as the bone marrow elements recovery were semi-quantitatively examined for each group. Excellent integration and biocompatibility behavior was observed in all groups. No adverse tissue responses were observed. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Biyoteknoloji | |
dc.subject | Fizikokimya | |
dc.subject | Polimer Karakterizasyonu | |
dc.subject | Temel Bilimler | |
dc.subject | Mühendislik ve Teknoloji | |
dc.subject | Mühendislik, Bilişim ve Teknoloji (ENG) | |
dc.subject | POLİMER BİLİMİ | |
dc.subject | Kimya | |
dc.subject | Malzeme Bilimi | |
dc.subject | MALZEME BİLİMİ, BİYOMATERYAL | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Mikrobiyoloji | |
dc.subject | BİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ | |
dc.title | A 6-month in vivo study of polymer/mesenchymal stem cell constructs for cranial defects | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | |
dc.contributor.department | Hacettepe Üniversitesi , Fen Bilimleri Enstitüsü , Biyomühendislik A.B.D. | |
dc.identifier.volume | 26 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 207 | |
dc.identifier.endpage | 221 | |
dc.contributor.firstauthorID | 75271 | |