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Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant-and prepubertal rats after pentylenetetrazole-induced seizure

dc.contributor.authorYorulmaz, Hatice
dc.contributor.authorKaptan, Engin
dc.contributor.authorCaglayan, Berrak
dc.contributor.authorOztas, Baria
dc.contributor.authorSeker, Fatma Burcu
dc.date.accessioned2021-03-02T20:19:29Z
dc.date.available2021-03-02T20:19:29Z
dc.date.issued2016
dc.identifier.citationSeker F. B. , Yorulmaz H., Kaptan E., Caglayan B., Oztas B., "Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant-and prepubertal rats after pentylenetetrazole-induced seizure", NUTRITIONAL NEUROSCIENCE, cilt.19, sa.2, ss.55-62, 2016
dc.identifier.issn1028-415X
dc.identifier.otherav_0164b538-7f7e-428a-b627-5c3b6c53b8f0
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/6916
dc.identifier.urihttps://doi.org/10.1179/1476830514y.0000000154
dc.description.abstractObjectives: Folic acid (FA) is physiologically important in mammals and is a common vitamin supplement used during pregnancy and lactation. Numerous studies have reported that FA significantly improves endothelial function. The blood-brain barrier (BBB) plays an important role in maintaining the microenvironment required for neuronal function, but its unique structure is damaged by epileptic seizures. The aim of this study was to evaluate the potential protective role of FA on BBB leakage, as well as on the reactive astrogliosis in pregnant rats and their prepubertal offspring during pentylenetetrazole (PTZ)-induced epileptic seizure.
dc.language.isoeng
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectBeslenme ve Dietetik
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTarım Bilimleri
dc.subjectBESLENME VE DİYETETİK
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSinirbilim ve Davranış
dc.subjectNEUROSCIENCES
dc.titleGestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant-and prepubertal rats after pentylenetetrazole-induced seizure
dc.typeMakale
dc.relation.journalNUTRITIONAL NEUROSCIENCE
dc.contributor.departmentYeditepe Üniversitesi , ,
dc.identifier.volume19
dc.identifier.issue2
dc.identifier.startpage55
dc.identifier.endpage62
dc.contributor.firstauthorID230043


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