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The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat

dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorAtukeren, Pınar
dc.contributor.authorGumustas, Koray
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorAlican, Inci
dc.contributor.authorIseri, Sevgin Ozlem
dc.date.accessioned2021-03-04T08:01:01Z
dc.date.available2021-03-04T08:01:01Z
dc.date.issued2009
dc.identifier.citationIseri S. O. , Ersoy Y., ERCAN F., YÜKSEL M., Atukeren P., Gumustas K., Alican I., "The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.24, sa.6, ss.1142-1148, 2009
dc.identifier.issn0815-9319
dc.identifier.otherav_61104277-2db7-46bb-9ab4-209f26e5b19b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/67706
dc.identifier.urihttps://doi.org/10.1111/j.1440-1746.2009.05797.x
dc.description.abstractSildenafil, a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE)5, has a relaxant effect on the smooth muscle cells of the arterioles supplying the human corpus cavernosum acting via nitric oxide (NO)-dependent mechanism. This study aimed to investigate the possible protective effect of sildenafil citrate on the extent of tissue integrity, oxidant-antioxidant status and neutrophil infiltration to the inflamed organ in a rat model of acetic acid-induced colitis.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.titleThe effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat
dc.typeMakale
dc.relation.journalJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
dc.contributor.departmentMarmara Üniversitesi , ,
dc.identifier.volume24
dc.identifier.issue6
dc.identifier.startpage1142
dc.identifier.endpage1148
dc.contributor.firstauthorID90410


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