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dc.contributor.authorBryois, Julien
dc.contributor.authorLi, Qingqin S.
dc.contributor.authorLucae, Susanne
dc.contributor.authorMadden, Pamela F. A.
dc.contributor.authorMagnusson, Patrik K.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMors, Ole
dc.contributor.authorMortensen, Preben Bo
dc.contributor.authorMueller-Myhsok, Bertram
dc.contributor.authorNordentoft, Merete
dc.contributor.authorNoethen, Markus M.
dc.contributor.authorO'Donovan, Michael C.
dc.contributor.authorPaciga, Sara A.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorPerlis, Roy H.
dc.contributor.authorPorteous, David J.
dc.contributor.authorPotash, James B.
dc.contributor.authorPreisig, Martin
dc.contributor.authorRietschel, Marcella
dc.contributor.authorSchaefer, Catherine
dc.contributor.authorSchulze, Thomas G.
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorStefansson, Kari
dc.contributor.authorTiemeier, Henning
dc.contributor.authorUher, Rudolf
dc.contributor.authorVoelzke, Henry
dc.contributor.authorWeissman, Myrna M.
dc.contributor.authorWerge, Thomas
dc.contributor.authorWinslow, Ashley R.
dc.contributor.authorLewis, Cathryn M.
dc.contributor.authorLevinson, Douglas F.
dc.contributor.authorBreen, Gerome
dc.contributor.authorBorglum, Anders D.
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorDirek, Neşe
dc.contributor.authorHomuth, Georg
dc.contributor.authorHorn, Carsten
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorHougaard, David M.
dc.contributor.authorHu, Ming
dc.contributor.authorHyde, Craig L.
dc.contributor.authorIsing, Marcus
dc.contributor.authorJansen, Rick
dc.contributor.authorJin, Fulai
dc.contributor.authorJorgenson, Eric
dc.contributor.authorKnowles, James A.
dc.contributor.authorKohane, Isaac S.
dc.contributor.authorKraft, Julia
dc.contributor.authorKretzschmar, Warren W.
dc.contributor.authorKrogh, Jesper
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorLane, Jacqueline M.
dc.contributor.authorLi, Yihan
dc.contributor.authorLi, Yun
dc.contributor.authorLind, Penelope A.
dc.contributor.authorLiu, Xiaoxiao
dc.contributor.authorLu, Leina
dc.contributor.authorMacIntyre, Donald J.
dc.contributor.authorMacKinnon, Dean F.
dc.contributor.authorMaier, Robert M.
dc.contributor.authorMaier, Wolfgang
dc.contributor.authorMarchini, Jonathan
dc.contributor.authorMbarek, Hamdi
dc.contributor.authorMcGrath, Patrick
dc.contributor.authorMcGuffin, Peter
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorMehta, Divya
dc.contributor.authorMiddeldorp, Christel M.
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMilani, Lili
dc.contributor.authorMill, Jonathan
dc.contributor.authorMondimore, Francis M.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMostafavi, Sara
dc.contributor.authorMullins, Niamh
dc.contributor.authorWray, Naomi R.
dc.contributor.authorRipke, Stephan
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorTrzaskowski, Maciej
dc.contributor.authorByrne, Enda M.
dc.contributor.authorAbdellaoui, Abdel
dc.contributor.authorAdams, Mark J.
dc.contributor.authorAgerbo, Esben
dc.contributor.authorAir, Tracy M.
dc.contributor.authorAndlauer, Till M. F.
dc.contributor.authorBacanu, Silviu-Alin
dc.contributor.authorBaekvad-Hansen, Marie
dc.contributor.authorBeekman, Aartjan F. T.
dc.contributor.authorBigdeli, Tim B.
dc.contributor.authorBinder, Elisabeth B.
dc.contributor.authorBlackwood, Douglas R. H.
dc.contributor.authorButtenschon, Henriette N.
dc.contributor.authorBybjerg-Grauholm, Jonas
dc.contributor.authorCai, Na
dc.contributor.authorCastelao, Enrique
dc.contributor.authorChristensen, Jane Hvarregaard
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorColeman, Jonathan I. R.
dc.contributor.authorColodro-Conde, Lucia
dc.contributor.authorCouvy-Duchesne, Baptiste
dc.contributor.authorCraddock, Nick
dc.contributor.authorCrawford, Gregory E.
dc.contributor.authorCrowley, Cheynna A.
dc.contributor.authorDashti, Hassan S.
dc.contributor.authorDavies, Gail
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dc.contributor.authorEscott-Price, Valentina
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dc.contributor.authorFinucane, Hilary K.
dc.contributor.authorForstner, Andreas J.
dc.contributor.authorFrank, Josef
dc.contributor.authorGaspar, Helena A.
dc.contributor.authorGill, Michael
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dc.contributor.authorGordon, Scott D.
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dc.contributor.authorHansen, Thomas F.
dc.contributor.authorHerms, Stefan
dc.contributor.authorHickie, Ian B.
dc.contributor.authorHoffmann, Per
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dc.contributor.authorO'Reilly, Paul F.
dc.contributor.authorOskarsson, Hogni
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dc.contributor.authorPainter, Jodie N.
dc.contributor.authorPedersen, Carsten Bocker
dc.contributor.authorPedersen, Marianne Giortz
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dc.contributor.authorPettersson, Erik
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dc.contributor.authorMirza, Saira Saeed
dc.contributor.authorSaxena, Richa
dc.contributor.authorSchoevers, Robert
dc.contributor.authorSchulte, Eva C.
dc.contributor.authorShen, Ling
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dc.contributor.authorShyn, Stanley I.
dc.contributor.authorSigurdsson, Engilbert
dc.contributor.authorSinnamon, Grant B. C.
dc.contributor.authorSmit, Johannes H.
dc.contributor.authorSmith, Daniel J.
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorSteinberg, Stacy
dc.contributor.authorStockmeier, Craig A.
dc.contributor.authorStreit, Fabian
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorTansey, Katherine E.
dc.contributor.authorTeismann, Henning
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThompson, Wesley
dc.contributor.authorThomson, Pippa A.
dc.contributor.authorThorgeirsson, Thorgeir E.
dc.contributor.authorTian, Chao
dc.contributor.authorTraylor, Matthew
dc.contributor.authorTreutlein, Jens
dc.contributor.authorTrubetskoy, Vassily
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorUmbricht, Daniel
dc.contributor.authorVan der Auwera, Sandra
dc.contributor.authorvan Hemert, Albert M.
dc.contributor.authorViktorin, Alexander
dc.contributor.authorVisscher, Peter M.
dc.contributor.authorWang, Yunpeng
dc.contributor.authorWebb, Bradley T.
dc.contributor.authorWeinsheimer, Shantel Marie
dc.contributor.authorWellmann, Juegen
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorWu, Yang
dc.contributor.authorXi, Hualin S.
dc.contributor.authorYang, Jian
dc.contributor.authorZhang, Futao
dc.contributor.authorArolt, Volker
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorBerger, Klaus
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorCichon, Sven
dc.contributor.authorDannlowski, Udo
dc.contributor.authorde Geus, E. C. J.
dc.contributor.authorDePaulo, J. Raymond
dc.contributor.authorDomenici, Enrico
dc.contributor.authorDomschke, Katharina
dc.contributor.authorEsko, Tonu
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorHamilton, Steven P.
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeath, Andrew C.
dc.contributor.authorHinds, David A.
dc.contributor.authorKendler, Kenneth S.
dc.contributor.authorKloiber, Stefan
dc.contributor.authorLewis, Glyn
dc.date.accessioned2021-03-04T07:54:27Z
dc.date.available2021-03-04T07:54:27Z
dc.date.issued2018
dc.identifier.citationWray N. R. , Ripke S., Mattheisen M., Trzaskowski M., Byrne E. M. , Abdellaoui A., Adams M. J. , Agerbo E., Air T. M. , Andlauer T. M. F. , et al., "Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression", NATURE GENETICS, cilt.50, sa.5, ss.668-683, 2018
dc.identifier.issn1061-4036
dc.identifier.othervv_1032021
dc.identifier.otherav_608947ff-9dc9-4e67-a75c-79beba828d17
dc.identifier.urihttp://hdl.handle.net/20.500.12627/67348
dc.identifier.urihttps://doi.org/10.1038/s41588-018-0090-3
dc.description.abstractMajor depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectGenetics
dc.subjectMolecular Biology
dc.subjectGenetics (clinical)
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectGENETİK VE HAYAT
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.titleGenome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
dc.typeMakale
dc.relation.journalNATURE GENETICS
dc.contributor.departmentUniv Med , ,
dc.identifier.volume50
dc.identifier.issue5
dc.identifier.startpage668
dc.identifier.endpage683
dc.contributor.firstauthorID2390242


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