dc.contributor.author | Aydin, Ali Emin | |
dc.contributor.author | Carin, Mahmut Nezih | |
dc.contributor.author | Turkmen, Aydin | |
dc.contributor.author | Sever, Mehmet S. | |
dc.contributor.author | Eldegez, Ulug | |
dc.contributor.author | Karahan, Gonca Emel | |
dc.contributor.author | Kekik, Cigdem | |
dc.contributor.author | Oguz, Fatma | |
dc.contributor.author | Onal, Ayşe Emel | |
dc.contributor.author | Bakkaloglu, Hueseyin | |
dc.contributor.author | Caliskan, Yasar Kerem | |
dc.contributor.author | Yazici, Halil | |
dc.date.accessioned | 2021-03-03T21:23:30Z | |
dc.date.available | 2021-03-03T21:23:30Z | |
dc.identifier.citation | Karahan G. E. , Kekik C., Oguz F., Onal A. E. , Bakkaloglu H., Caliskan Y. K. , Yazici H., Turkmen A., Aydin A. E. , Sever M. S. , et al., "Association of HLA phenotypes of end-stage renal disease patients preparing for first transplantation with anti-HLA antibody status.", Renal failure, cilt.32, ss.380-3, 2010 | |
dc.identifier.issn | 0886-022X | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_5ee664ea-eb79-4d99-ae29-69a2df46065a | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/66331 | |
dc.identifier.uri | https://doi.org/10.3109/08860221003615803 | |
dc.description.abstract | Patients with pre-transplantation high levels of panel reactive antibody (PRA) have an increased risk of graft failure, and renal transplantation in sensitized patients remains a highly significant challenge worldwide. The influence of anti-human leukocyte antigen (HLA) antibodies on the development of rejection episodes depends on patient-specific clinical factors and differs from patient to patient. The HLA typing of the recipient might influence the development of anti-HLA antibodies. Some HLA antigens appear to be more immunogenic than others. The aim of this study is to demonstrate the distribution of HLA phenotypes in PRA-positive and PRA-negative end-stage renal disease (ESRD) patients on the basis of having sensitizing events or not. Our study included 642 (mean age: 41.54; female/male: 310/332) ESRD patients preparing for the first transplantation and who are on the cadaveric kidney transplantation waiting list of Istanbul Medical Faculty in 2008-2009. Class I HLA-A,B typing was performed by complement-dependent cytotoxicity (CDC) method, whereas class II HLA-DRB1 typing was performed by low-resolution polymerase chain reaction (PCR)-sequence-specific primer (SSP). All serum samples were screened for the presence of IgG type of anti-HLA class I- and II-specific antibodies by enzyme-linked-immunosorbent assay (ELISA). PRA-negative group consisted of 558 (86.9%) and PRA-positive group included 84 (13.1%) patients. We have found statistically significant frequency of HLA-A3 (p = 0.018), HLA-A66 (p = 0.04), and HLA-B18 (p = 0.006) antigens in PRA-positive patients and DRB1*07 (p = 0.02) having the highest frequency in patients with sensitizing event history but no anti-HLA development suggesting that DRB1*07 might be associated with low risk of anti-HLA antibody formation.</. | |
dc.language.iso | eng | |
dc.subject | Nefroloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ÜROLOJİ VE NEFROLOJİ | |
dc.title | Association of HLA phenotypes of end-stage renal disease patients preparing for first transplantation with anti-HLA antibody status. | |
dc.type | Makale | |
dc.relation.journal | Renal failure | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 32 | |
dc.identifier.startpage | 380 | |
dc.identifier.endpage | 3 | |
dc.contributor.firstauthorID | 2484492 | |