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dc.contributor.authorAydin, Ali Emin
dc.contributor.authorCarin, Mahmut Nezih
dc.contributor.authorTurkmen, Aydin
dc.contributor.authorSever, Mehmet S.
dc.contributor.authorEldegez, Ulug
dc.contributor.authorKarahan, Gonca Emel
dc.contributor.authorKekik, Cigdem
dc.contributor.authorOguz, Fatma
dc.contributor.authorOnal, Ayşe Emel
dc.contributor.authorBakkaloglu, Hueseyin
dc.contributor.authorCaliskan, Yasar Kerem
dc.contributor.authorYazici, Halil
dc.date.accessioned2021-03-03T21:23:30Z
dc.date.available2021-03-03T21:23:30Z
dc.identifier.citationKarahan G. E. , Kekik C., Oguz F., Onal A. E. , Bakkaloglu H., Caliskan Y. K. , Yazici H., Turkmen A., Aydin A. E. , Sever M. S. , et al., "Association of HLA phenotypes of end-stage renal disease patients preparing for first transplantation with anti-HLA antibody status.", Renal failure, cilt.32, ss.380-3, 2010
dc.identifier.issn0886-022X
dc.identifier.othervv_1032021
dc.identifier.otherav_5ee664ea-eb79-4d99-ae29-69a2df46065a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/66331
dc.identifier.urihttps://doi.org/10.3109/08860221003615803
dc.description.abstractPatients with pre-transplantation high levels of panel reactive antibody (PRA) have an increased risk of graft failure, and renal transplantation in sensitized patients remains a highly significant challenge worldwide. The influence of anti-human leukocyte antigen (HLA) antibodies on the development of rejection episodes depends on patient-specific clinical factors and differs from patient to patient. The HLA typing of the recipient might influence the development of anti-HLA antibodies. Some HLA antigens appear to be more immunogenic than others. The aim of this study is to demonstrate the distribution of HLA phenotypes in PRA-positive and PRA-negative end-stage renal disease (ESRD) patients on the basis of having sensitizing events or not. Our study included 642 (mean age: 41.54; female/male: 310/332) ESRD patients preparing for the first transplantation and who are on the cadaveric kidney transplantation waiting list of Istanbul Medical Faculty in 2008-2009. Class I HLA-A,B typing was performed by complement-dependent cytotoxicity (CDC) method, whereas class II HLA-DRB1 typing was performed by low-resolution polymerase chain reaction (PCR)-sequence-specific primer (SSP). All serum samples were screened for the presence of IgG type of anti-HLA class I- and II-specific antibodies by enzyme-linked-immunosorbent assay (ELISA). PRA-negative group consisted of 558 (86.9%) and PRA-positive group included 84 (13.1%) patients. We have found statistically significant frequency of HLA-A3 (p = 0.018), HLA-A66 (p = 0.04), and HLA-B18 (p = 0.006) antigens in PRA-positive patients and DRB1*07 (p = 0.02) having the highest frequency in patients with sensitizing event history but no anti-HLA development suggesting that DRB1*07 might be associated with low risk of anti-HLA antibody formation.</.
dc.language.isoeng
dc.subjectNefroloji
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.titleAssociation of HLA phenotypes of end-stage renal disease patients preparing for first transplantation with anti-HLA antibody status.
dc.typeMakale
dc.relation.journalRenal failure
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume32
dc.identifier.startpage380
dc.identifier.endpage3
dc.contributor.firstauthorID2484492


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