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dc.contributor.authorYanardag, Refiye
dc.contributor.authorBayrak, Bertan Boran
dc.contributor.authorTurkyilmaz, Ismet Burcu
dc.contributor.authorAkev, Nuriye
dc.contributor.authorSacan, Ozlem
dc.contributor.authorMutlu, Ozgur
dc.date.accessioned2021-03-03T21:09:37Z
dc.date.available2021-03-03T21:09:37Z
dc.date.issued2016
dc.identifier.citationSacan O., Turkyilmaz I. B. , Bayrak B. B. , Mutlu O., Akev N., Yanardag R., "Zinc supplementation ameliorates glycoprotein components and oxidative stress changes in the lung of streptozotocin diabetic rats", BIOMETALS, cilt.29, sa.2, ss.239-248, 2016
dc.identifier.issn0966-0844
dc.identifier.otherav_5db70ff9-0f44-44e8-8087-110de3720e3b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/65578
dc.identifier.urihttps://doi.org/10.1007/s10534-016-9911-y
dc.description.abstractZinc (Zn) is a component of numerous enzymes that function in a wide range of biological process, including growth, development, immunity and intermediary metabolism. Zn may play a role in chronic states such as cardiovascular disease and diabetes mellitus. Zn acts as cofactor and for many enzymes and proteins and has antioxidant, antiinflammatory and antiapoptotic effects. Taking into consideration that lung is a possible target organ for diabetic complications, the aim of this study was to investigate the protective role of zinc on the glycoprotein content and antioxidant enzyme activities of streptozotocin (STZ) induced diabetic rat tissues. Female Swiss albino rats were divided into four groups. Group I, control; Group II, control + zinc sulfate; Group III, STZ-diabetic; Group IV, diabetic + zinc sulfate. Diabetes was induced by intraperitoneal injection of STZ (65 mg/kg body weight). Zinc sulfate was given daily by gavage at a dose of 100 mg/kg body weight every day for 60 days to groups II and IV. At the last day of the experiment, rats were sacrificed, lung tissues were taken. Also, glycoprotein components, tissue factor (TF) activity, protein carbonyl (PC), advanced oxidative protein products (AOPP), hydroxyproline, and enzyme activities in lung tissues were determined. Glycoprotein components, TF activity, lipid peroxidation, non enzymatic glycation, PC, AOPP, hydroxyl proline, lactate dehydrogenase, catalase, superoxide dismutase, myeloperoxidase, xanthine oxidase, adenosine deaminase and prolidase significantly increased in lung tissues of diabetic rats. Also, glutathione levels, paraoxonase, arylesterase, carbonic anhydrase, and Na+/K+- ATPase activities were decreased. Administration of zinc significantly reversed these effects. Thus, the study indicates that zinc possesses a significantly beneficial effect on the glycoprotein components and oxidant/antioxidant enzyme activities.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectSitogenetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleZinc supplementation ameliorates glycoprotein components and oxidative stress changes in the lung of streptozotocin diabetic rats
dc.typeMakale
dc.relation.journalBIOMETALS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume29
dc.identifier.issue2
dc.identifier.startpage239
dc.identifier.endpage248
dc.contributor.firstauthorID79368


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