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Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical study

dc.contributor.authorTurkay, C.
dc.contributor.authorUlkay, M. B.
dc.contributor.authorBurakgazi, A. Z.
dc.contributor.authorIlhan, A.
dc.contributor.authorAktaş, Abit
dc.contributor.authorUzar, E.
dc.contributor.authorÖzay, Rafet
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorUyar, M. E.
dc.contributor.authorErsoy, A.
dc.date.accessioned2021-03-03T20:49:07Z
dc.date.available2021-03-03T20:49:07Z
dc.date.issued2012
dc.identifier.citationUzar E., Özay R., Evliyaoglu O., Aktaş A., Ulkay M. B. , Uyar M. E. , Ersoy A., Burakgazi A. Z. , Turkay C., Ilhan A., "Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical study", HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.31, sa.10, ss.1066-1073, 2012
dc.identifier.issn0960-3271
dc.identifier.othervv_1032021
dc.identifier.otherav_5c00e1fa-be8e-45dc-a402-500a4bcc15f4
dc.identifier.urihttp://hdl.handle.net/20.500.12627/64518
dc.identifier.urihttps://doi.org/10.1177/0960327111433183
dc.description.abstractThe aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle tissues were analyzed, and stereological analysis of the sciatic nerve was performed. Levels of malondialdehyde and nitric oxide in the tissues were significantly higher in the HCQ group than in the control group (p < 0.05). In addition, activities of superoxide dismutase and glutathione peroxidase were found to be significantly higher in the HCQ group than the control group (p < 0.05). There were significant decreases in nerve fiber diameter and myelin sheet thickness in the HCQ group compared with the control group (p < 0.05). These results revealed that HCQ might increase oxidative stress on sciatic nerve and muscle tissues of rats, which may correlate with axonal atrophy in sciatic nerves.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectEczacılık
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTOKSİKOLOJİ
dc.subjectYaşam Bilimleri
dc.titleHydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical study
dc.typeMakale
dc.relation.journalHUMAN & EXPERIMENTAL TOXICOLOGY
dc.contributor.departmentDicle Üniversitesi , ,
dc.identifier.volume31
dc.identifier.issue10
dc.identifier.startpage1066
dc.identifier.endpage1073
dc.contributor.firstauthorID67795


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