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dc.contributor.authorBaran, Elif
dc.contributor.authorEnginar, NURHAN
dc.contributor.authorNurten, Asiye
dc.contributor.authorZengin, Asli
dc.contributor.authorKaramursel, Yesim
dc.date.accessioned2021-03-03T20:42:01Z
dc.date.available2021-03-03T20:42:01Z
dc.date.issued2010
dc.identifier.citationEnginar N., Nurten A., Karamursel Y., Zengin A., Baran E., "Scopolamine-induced convulsions in fasted mice after food intake: Evaluation of the sedative effect in the suppression of convulsions", EPILEPSY RESEARCH, cilt.89, sa.1, ss.2-6, 2010
dc.identifier.issn0920-1211
dc.identifier.otherav_5b421115-6ee0-4ddc-9648-835ac81fe80d
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/64080
dc.identifier.urihttps://doi.org/10.1016/j.eplepsyres.2009.10.011
dc.description.abstractFood intake triggers convulsions in fasted mice and rats treated with antimuscarinic drugs, scopolamine or atropine. Most of the drugs produced anticonvulsant efficacy in these convulsions have sedative effects. Thus, the present study was performed to evaluate the contribution of sedation in the suppression of convulsions by using sedative drugs chlorpromazine, morphine, amitriptyline and diphenhydramine. Mice fasted for 24 h and treated with 3 mg/kg scopolamine developed convulsions soon after refeeding. Treatment of chlorpromazine and morphine during food deprivation did not provide a preventive effect in the development of convulsions observed after food intake in fasted animals. Pretreatment of amitriptyline, but not diphenhydramine, before scopolamine treatment suppressed the incidence of convulsions. Present results could not clearly demonstrate the role played by sedative effect in suppression of convulsions in fasted animals. (C) 2009 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectNöroloji
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleScopolamine-induced convulsions in fasted mice after food intake: Evaluation of the sedative effect in the suppression of convulsions
dc.typeMakale
dc.relation.journalEPILEPSY RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume89
dc.identifier.issue1
dc.identifier.startpage2
dc.identifier.endpage6
dc.contributor.firstauthorID7205


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