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Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives

dc.contributor.authorSalman, Aydin
dc.contributor.authorGuzel, Ozlen
dc.contributor.authorKarali, Nilguen
dc.date.accessioned2021-03-03T20:27:33Z
dc.date.available2021-03-03T20:27:33Z
dc.date.issued2008
dc.identifier.citationGuzel O., Karali N., Salman A., "Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, cilt.16, sa.19, ss.8976-8987, 2008
dc.identifier.issn0968-0896
dc.identifier.otherav_5a0a324e-78b1-4358-b81e-7249de167b84
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/63302
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2008.08.050
dc.description.abstractNew series of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazones 3a-t, 1-methyl-5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazones 4a-y and 5-trifluoromethoxy-1-morpholinomethyl-1H-indole-2,3-dione 3-thiosemicarbazones 5a-m were synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new 5-methyl/trifluoromethoxy-1H-indole-2,3-dione derivatives, along with previously synthesized 5-methyl-1H-indole-2,3-dione 3-thiosemicarbazones 6a-1, were evaluated for in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv. 5-Methyl-1H-indole-2,3-dione 3-thiosemicarbazones (3b, 3d, 3f, 6c, 6d, and 6f), 5-trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazones (3q-s) and 5-trifluoromethoxy-1-morpholinomethyl-1H-indole-2,3-dione 3-thiosemicarbazones (5e and 5j-1) were found to be the most potent inhibitors of M. tuberculosis growth described in this study. (C) 2008 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectKİMYA, ORGANİK
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleSynthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives
dc.typeMakale
dc.relation.journalBIOORGANIC & MEDICINAL CHEMISTRY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume16
dc.identifier.issue19
dc.identifier.startpage8976
dc.identifier.endpage8987
dc.contributor.firstauthorID47675


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