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dc.contributor.authorDireskeneli, H.
dc.contributor.authorOzen, G.
dc.contributor.authorWREN, J. D.
dc.contributor.authorSAWALHA, A. H.
dc.contributor.authorYilmaz, VUSLAT
dc.contributor.authorSaruhan-Direskeneli, G.
dc.contributor.authorTulunay, A.
dc.contributor.authorDOZMOROV, M. G.
dc.contributor.authorTure-Ozdemir, F.
dc.contributor.authorEksioglu-Demiralp, E.
dc.contributor.authorAlibaz-Oner, F.
dc.date.accessioned2021-03-03T20:17:38Z
dc.date.available2021-03-03T20:17:38Z
dc.date.issued2015
dc.identifier.citationTulunay A., DOZMOROV M. G. , Ture-Ozdemir F., Yilmaz V., Eksioglu-Demiralp E., Alibaz-Oner F., Ozen G., WREN J. D. , Saruhan-Direskeneli G., SAWALHA A. H. , et al., "Activation of the JAK/STAT pathway in Behcet's disease", GENES AND IMMUNITY, cilt.16, sa.2, ss.170-175, 2015
dc.identifier.issn1466-4879
dc.identifier.othervv_1032021
dc.identifier.otherav_592796eb-d1de-4930-b30b-7b6203b3f06c
dc.identifier.urihttp://hdl.handle.net/20.500.12627/62736
dc.identifier.urihttps://doi.org/10.1038/gene.2014.64
dc.description.abstractTh1/Th17-type T-cell responses are upregulated in Behcet's disease (BD). However, signaling pathways associated with this aberrant immune response are not clarified. Whole-genome microarray profiling was performed with human U133 (Plus 2.0) chips using messenger RNA of isolated CD14(+) monocytes and CD4(+) T cells from peripheral blood mononucleated cell (PBMC) in patients with BD (n = 9) and healthy controls (HCs) (n = 9). Flow cytometric analysis of unstimulated (US) and stimulated (phytohaemagglutinin) signal transducer and activator of transcription (STAT3) and pSTAT3 expressions of PBMCs were also analyzed (BD and HC, both n = 26). Janus family of kinase (JAK1) was observed to be upregulated in both CD14(+) monocytes (1.95-fold) and CD4(+) T lymphocytes (1.40-fold) of BD patients. Using canonical pathway enrichment analysis, JAK/STAT signaling was identified as activated in both CD14(+) monocytes (P = 9.55E - 03) and in CD4(+) lymphocytes (P = 8.13E - 04) in BD. Interferon signaling was also prominent among upregulated genes in CD14(+) monocytes (P = 5.62E -05). Glucocorticoid receptor signaling and interleukin (IL-6) signaling were among the most enriched pathways in differentially expressed genes in CD14(+) monocytes (P = 2.45E - 09 and 1.00E - 06, respectively). Basal US total STAT3 expression was significantly higher in BD (1.2 vs 3.45, P < 0.05). The JAK1/STAT3 signaling pathway is activated in BD, possibly through the activation of Th1/Th17-type cytokines such as IL-2, interferon (IFN-gamma), IL-6, IL-17 and IL-23.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectGENETİK VE HAYAT
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTıbbi Genetik
dc.titleActivation of the JAK/STAT pathway in Behcet's disease
dc.typeMakale
dc.relation.journalGENES AND IMMUNITY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume16
dc.identifier.issue2
dc.identifier.startpage170
dc.identifier.endpage175
dc.contributor.firstauthorID101114


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