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dc.contributor.authorGuel, Ahmet
dc.contributor.authorSaruhan-Direskeneli, Güher
dc.contributor.authorKANEKO, Fumio
dc.contributor.authorTugal-Tutkun, Ilknur
dc.contributor.authorYENTUER, Sibel Penbe
dc.contributor.authorKULABER, Ayla
dc.contributor.authorAKMAN-DEMIR, Guelsen
dc.date.accessioned2021-03-03T20:08:02Z
dc.date.available2021-03-03T20:08:02Z
dc.date.issued2007
dc.identifier.citationKULABER A., Tugal-Tutkun I., YENTUER S. P. , AKMAN-DEMIR G., KANEKO F., Guel A., Saruhan-Direskeneli G., "Pro-inflammatory cellular immune response in Behçet's disease", Rheumatology International, cilt.27, sa.12, ss.1113-1118, 2007
dc.identifier.issn0172-8172
dc.identifier.othervv_1032021
dc.identifier.otherav_584757bd-e975-4434-b802-a9572e6d194e
dc.identifier.urihttp://hdl.handle.net/20.500.12627/62172
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548514197&origin=inward
dc.identifier.urihttps://doi.org/10.1007/s00296-007-0367-9
dc.description.abstractSeveral proteins are investigated as candidate auto-antigens in the pathogenesis of Behçet's disease (BD). This study aimed to screen the cellular responses to auto-antigen (αB-crystallin, αBC), and microorganism (Streptococcus sangius KTH-1 BES-1 protein) derived peptides as well as to isopentenyl pyrophosphate (IPP). Peripheral blood mononuclear cells (PBMC) from 22 BD patients and 22 healthy controls (HC) were stimulated in vitro with αBC, BES-1 peptides, IPP and PPD and induced proliferation as well as the secreted interleukin (IL)-12 and interferon (IFN)-γ production levels were measured. We did not observe any significant difference in cellular proliferation between BD patients and HC. Induction of IL-12 secretion with αBC was stronger in BD patients (P = 0.04) and in the disease subgroup with uveitis (P = 0.027) compared the HC. When responses to PPD were compared, proliferation of PMBC was lower (P = 0.03), whereas IL-12 secretion was higher in BD (P = 0.04) as well as in patients under colchicum treatment (P = 0.04) and with vascular involvement (P = 0.006) compared to HC. BES-1373-385 peptide induced also higher IL-12 productions by PBMC of BD patients (P = 0.017) and of patients with uveitis (P = 0.013). Finally, IPP stimulated higher IL-12 secretions from PBMC in BD patients (P = 0.035) and in patients with (P = 0.02) or without (P = 0.017) uveitis or arthritis (P = 0.04), under colchicum treatment (P = 0.01) or not receiving any immunosuppressive treatment (P = 0.007) compared to HC. These results suggest a more prominent pro-inflammatory cytokine secretion from PBMC in BD patients compared to HC in response to various antigens including αBC protein, BES-1373-385, IPP and PPD. © 2007 Springer-Verlag.
dc.language.isoeng
dc.subjectİmmünoloji ve Romatoloji
dc.subjectİç Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectROMATOLOJİ
dc.titlePro-inflammatory cellular immune response in Behçet's disease
dc.typeMakale
dc.relation.journalRheumatology International
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume27
dc.identifier.issue12
dc.identifier.startpage1113
dc.identifier.endpage1118
dc.contributor.firstauthorID25166


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