dc.contributor.author | Guel, Ahmet | |
dc.contributor.author | Saruhan-Direskeneli, Güher | |
dc.contributor.author | KANEKO, Fumio | |
dc.contributor.author | Tugal-Tutkun, Ilknur | |
dc.contributor.author | YENTUER, Sibel Penbe | |
dc.contributor.author | KULABER, Ayla | |
dc.contributor.author | AKMAN-DEMIR, Guelsen | |
dc.date.accessioned | 2021-03-03T20:08:02Z | |
dc.date.available | 2021-03-03T20:08:02Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | KULABER A., Tugal-Tutkun I., YENTUER S. P. , AKMAN-DEMIR G., KANEKO F., Guel A., Saruhan-Direskeneli G., "Pro-inflammatory cellular immune response in Behçet's disease", Rheumatology International, cilt.27, sa.12, ss.1113-1118, 2007 | |
dc.identifier.issn | 0172-8172 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_584757bd-e975-4434-b802-a9572e6d194e | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/62172 | |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548514197&origin=inward | |
dc.identifier.uri | https://doi.org/10.1007/s00296-007-0367-9 | |
dc.description.abstract | Several proteins are investigated as candidate auto-antigens in the pathogenesis of Behçet's disease (BD). This study aimed to screen the cellular responses to auto-antigen (αB-crystallin, αBC), and microorganism (Streptococcus sangius KTH-1 BES-1 protein) derived peptides as well as to isopentenyl pyrophosphate (IPP). Peripheral blood mononuclear cells (PBMC) from 22 BD patients and 22 healthy controls (HC) were stimulated in vitro with αBC, BES-1 peptides, IPP and PPD and induced proliferation as well as the secreted interleukin (IL)-12 and interferon (IFN)-γ production levels were measured. We did not observe any significant difference in cellular proliferation between BD patients and HC. Induction of IL-12 secretion with αBC was stronger in BD patients (P = 0.04) and in the disease subgroup with uveitis (P = 0.027) compared the HC. When responses to PPD were compared, proliferation of PMBC was lower (P = 0.03), whereas IL-12 secretion was higher in BD (P = 0.04) as well as in patients under colchicum treatment (P = 0.04) and with vascular involvement (P = 0.006) compared to HC. BES-1373-385 peptide induced also higher IL-12 productions by PBMC of BD patients (P = 0.017) and of patients with uveitis (P = 0.013). Finally, IPP stimulated higher IL-12 secretions from PBMC in BD patients (P = 0.035) and in patients with (P = 0.02) or without (P = 0.017) uveitis or arthritis (P = 0.04), under colchicum treatment (P = 0.01) or not receiving any immunosuppressive treatment (P = 0.007) compared to HC. These results suggest a more prominent pro-inflammatory cytokine secretion from PBMC in BD patients compared to HC in response to various antigens including αBC protein, BES-1373-385, IPP and PPD. © 2007 Springer-Verlag. | |
dc.language.iso | eng | |
dc.subject | İmmünoloji ve Romatoloji | |
dc.subject | İç Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ROMATOLOJİ | |
dc.title | Pro-inflammatory cellular immune response in Behçet's disease | |
dc.type | Makale | |
dc.relation.journal | Rheumatology International | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 27 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1113 | |
dc.identifier.endpage | 1118 | |
dc.contributor.firstauthorID | 25166 | |