dc.contributor.author | Bekpmar, S | |
dc.contributor.author | Unlucerci, YMY | |
dc.contributor.author | Seferoglu, G | |
dc.date.accessioned | 2021-03-03T19:55:14Z | |
dc.date.available | 2021-03-03T19:55:14Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Unlucerci Y., Bekpmar S., Seferoglu G., "The effect of aminoguanidine on urinary heparan sulphate levels in experimental diabetes", ACTA DIABETOLOGICA, cilt.37, sa.2, ss.71-76, 2000 | |
dc.identifier.issn | 0940-5429 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_57182c71-502c-4397-82cb-768fd39f7cb8 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/61453 | |
dc.identifier.uri | https://doi.org/10.1007/s005920070022 | |
dc.description.abstract | In the present study, we investigated whether the ameliorating effect of aminoguanidine on diabetes-related proteinuria and nephropathy is associated with glomerular basement membrane heparan sulphate contents. STZ-induced diabetic rats developed proteinuria (at the tenth week: diabetic rats, 713 +/- 418 mg protein per millimole creatinine; control rats, g/mmol creatinine; control rats, 41 +/- 13; p < 0.001), suggesting loss of glomerular basement membrane charge. Aminoguanidine treatment of diabetic rats diminished urinary heparan sulphate levels (196 +/- 52), suggesting high incorporation of heparan sulphate-associated charge into glomerular basement membrane. Aminoguanidine administration to diabetic rats also relatively improved proteinuria (456 +/- 255). It is concluded that aminoguanidine treatment has a relative beneficial effect by restoring the diabetes-induced change in renal basement membrane heparan sulphate levels. | |
dc.language.iso | eng | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.title | The effect of aminoguanidine on urinary heparan sulphate levels in experimental diabetes | |
dc.type | Makale | |
dc.relation.journal | ACTA DIABETOLOGICA | |
dc.contributor.department | , , | |
dc.identifier.volume | 37 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 71 | |
dc.identifier.endpage | 76 | |
dc.contributor.firstauthorID | 125791 | |