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dc.contributor.authorKarabulut, S
dc.contributor.authorBılgın, Ersel
dc.contributor.authorTas, Faruk
dc.contributor.authorDuranyıldız, D
dc.date.accessioned2021-03-03T19:43:44Z
dc.date.available2021-03-03T19:43:44Z
dc.date.issued2016
dc.identifier.citationTas F., Bılgın E., Karabulut S., Duranyıldız D., "Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients", MOLECULAR AND CLINICAL ONCOLOGY, cilt.5, sa.1, ss.195-200, 2016
dc.identifier.othervv_1032021
dc.identifier.otherav_5621f446-919d-466a-a65b-8ff2028f30d9
dc.identifier.urihttp://hdl.handle.net/20.500.12627/60826
dc.identifier.urihttps://doi.org/10.3892/mco.2016.873
dc.description.abstractLaminin and type-IV collagen constitute a significant portion of the extracellular matrix. The objective of the present study was to evaluate whether the serum concentrations of laminin and type-IV collagen may serve as biomarkers for cutaneous melanoma. Sixty pathologically confirmed melanoma patients were enrolled in the study. Serum laminin and type-IV collagen levels were assessed using an ELISA. Thirty healthy controls were also examined. No significant differences in the baseline serum levels of laminin were identified between melanoma patients and healthy controls (P=0.45). However, the baseline serum levels of type-IV collagen were significantly elevated in melanoma patients compared with those in the control group (P0.05). Furthermore, the serum levels of laminin and type-IV collagen had no prognostic value regarding the outcome for melanoma patients (P=0.36 and P=0.26, respectively). While laminin levels showed no diagnostic value, the serum concentrations of type-IV collagen were indicated to serve as a diagnostic marker in patients with cutaneous melanoma. In conclusion, type-IV collagen levels may be used as a diagnostic marker for cutaneous melanoma, while being void of any prognostic value.
dc.language.isoeng
dc.subjectOnkoloji
dc.subjectOncology
dc.subjectHealth Sciences
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectONKOLOJİ
dc.titleClinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients
dc.typeMakale
dc.relation.journalMOLECULAR AND CLINICAL ONCOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume5
dc.identifier.issue1
dc.identifier.startpage195
dc.identifier.endpage200
dc.contributor.firstauthorID2195371


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