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Genotoxic potential of cyclosporin A in patients with renal transplantation

dc.contributor.authorGuler, K
dc.contributor.authorPalanduz, S
dc.contributor.authorSever, MS
dc.contributor.authorTascioglu, C
dc.contributor.authorKaran, MA
dc.contributor.authorSonmez, G
dc.contributor.authorOzturk, S
dc.contributor.authorCefle, K
dc.date.accessioned2021-03-03T19:41:18Z
dc.date.available2021-03-03T19:41:18Z
dc.date.issued1999
dc.identifier.citationPalanduz S., Sever M., Ozturk S., Tascioglu C., Karan M., Sonmez G., Cefle K., Guler K., "Genotoxic potential of cyclosporin A in patients with renal transplantation", CELL BIOLOGY AND TOXICOLOGY, cilt.15, sa.1, ss.13-17, 1999
dc.identifier.issn0742-2091
dc.identifier.otherav_55e75f8a-3e03-43d3-9c27-85982caff51d
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/60667
dc.identifier.urihttps://doi.org/10.1023/a:1007594421458
dc.description.abstractWe analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in viva induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.
dc.language.isoeng
dc.subjectFarmasötik Toksikoloji
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.titleGenotoxic potential of cyclosporin A in patients with renal transplantation
dc.typeMakale
dc.relation.journalCELL BIOLOGY AND TOXICOLOGY
dc.contributor.department, ,
dc.identifier.volume15
dc.identifier.issue1
dc.identifier.startpage13
dc.identifier.endpage17
dc.contributor.firstauthorID122637


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