dc.contributor.author | Kadioglu, A. | |
dc.contributor.author | Kilicaslan, Işın | |
dc.contributor.author | Tefekli, A. | |
dc.contributor.author | Akman, T. | |
dc.contributor.author | Armagan, A. | |
dc.contributor.author | Ozerman, B. | |
dc.contributor.author | Tepeler, A. | |
dc.date.accessioned | 2021-03-03T19:31:10Z | |
dc.date.available | 2021-03-03T19:31:10Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Akman T., Tefekli A., Armagan A., Kilicaslan I., Ozerman B., Tepeler A., Kadioglu A., "Decorin as a new treatment alternative in Peyronie's disease: preliminary results in the rat model", ANDROLOGIA, cilt.45, sa.2, ss.101-106, 2013 | |
dc.identifier.issn | 0303-4569 | |
dc.identifier.other | av_54fd40b7-471d-4d09-8208-21ceb523e479 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/60121 | |
dc.identifier.uri | https://doi.org/10.1111/j.1439-0272.2012.01318.x | |
dc.description.abstract | The purpose of this study is to investigate the effect of decorin, a naturally occurring proteoglycan with anti-transforming growth factor beta (TGF-) activity, on the rat model of Peyronie's disease (PD). Twenty-five adult male Sprague-Dawley rats were divided in three groups: I) TGF- (0.5g) injected (n: 8); II) TGF- injected and decorin treated (n: 8); and III) controls (n: 9). Decorin (0.5g per day) was given with intracavernous injection on the second, third, fourth and fifth day following TGF- injection. All rats underwent electrical stimulation of the cavernous nerve after 6weeks. Intracavernosal and arterial blood pressures were measured during this procedure. Cross-sections of the rat penises were examined using Mason trichrome and H&E stains. Statistical analyses were carried out using one-way anova. Histopathological examinations confirmed the Peyronie's-like condition in TGF--injected rats, which exhibited a thickening of the tunica albuginea (TA), when compared to controls. Disorganisation of collagen on the TA was also prominent in TGF--injected rats, but not in decorin-treated and control rats. Decorin-treated rats showed significantly higher maximal intracavernosal pressure (MIP) responses to cavernous nerve stimulation, when compared to group 1 (P<0.05). Our results indicate that decorin antagonises the effects of TGF- in the rat model of PD and prevents diminished erectile response to cavernous nerve stimulation. | |
dc.language.iso | eng | |
dc.subject | İç Hastalıkları | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ANDROLOJİ | |
dc.title | Decorin as a new treatment alternative in Peyronie's disease: preliminary results in the rat model | |
dc.type | Makale | |
dc.relation.journal | ANDROLOGIA | |
dc.contributor.department | Bezmiâlem Vakıf Üniversitesi , , | |
dc.identifier.volume | 45 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 101 | |
dc.identifier.endpage | 106 | |
dc.contributor.firstauthorID | 20283 | |