dc.contributor.author | Bal, C | |
dc.contributor.author | Mangold, P | |
dc.contributor.author | Amann, S | |
dc.contributor.author | Akalin, E | |
dc.contributor.author | Ang, O | |
dc.contributor.author | Casellas, JM | |
dc.contributor.author | Bauernfeind, A | |
dc.contributor.author | Stemplinger, I | |
dc.contributor.author | Jungwirth, R | |
dc.date.accessioned | 2021-03-03T17:59:57Z | |
dc.date.available | 2021-03-03T17:59:57Z | |
dc.date.issued | 1996 | |
dc.identifier.citation | Bauernfeind A., Stemplinger I., Jungwirth R., Mangold P., Amann S., Akalin E., Ang O., Bal C., Casellas J., "Characterization of beta-lactamase gene bla(PER-2,) which encodes an extended-spectrum class A beta-lactamase", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.40, sa.3, ss.616-620, 1996 | |
dc.identifier.issn | 0066-4804 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_4ca8db35-f273-4d37-bb34-e10bc1bd27de | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/54880 | |
dc.identifier.uri | https://doi.org/10.1128/aac.40.3.616 | |
dc.description.abstract | Plasmidic extended-spectrum beta-lactamases of Ambler class A are mostly inactive against ceftibuten. Salmonella typhimurium JMC isolated in Argentina harbors a bla gene located on a plasmid (pMVP-5) which confers transferable resistance to oxyiminocephalosporins, aztreonam, and ceftibuten. The beta-lactamase PER-2 (formerly ceftibutenase-1; CTI-1) is highly susceptible to inhibition by clavulanate and is located at a pI of 5.4 after isoelectric focusing, The bla(PER-2) gene was cloned and sequenced. The nucleotide sequence of a 2.2-kb insert in vector pBluescript includes an open reading frame of 927 bp. Comparison of the deduced amino acid sequence of PER-2 with those of other beta-lactamases indicates that PER-2 is not closely related to TEM or SHV enzymes (25 to 26% homology), PER-2 is most closely related to PER-1 (86.4% homology), an Ambler class A enzyme first detected in Pseudomonas aeruginosa, An enzyme with an amino acid sequence identical to that of PER-1, meanwhile, was found in various members of the family Enterobacteriaceae isolated from patients in Turkey. Our data indicate that PER-2 and PER-1 represent a new group of Ambler class A extended-spectrum beta-lactamases. PER-2 so far has been detected only in pathogens (S. typhimurium, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis) isolated from patients in South America, while the incidence of PER-1-producing strains so far has been restricted to Turkey, where it occurs both in members of the family Enterobacteriaceae and in P. aeruginosa. | |
dc.language.iso | eng | |
dc.subject | Eczacılık | |
dc.subject | Mikrobiyoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.title | Characterization of beta-lactamase gene bla(PER-2,) which encodes an extended-spectrum class A beta-lactamase | |
dc.type | Makale | |
dc.relation.journal | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | |
dc.contributor.department | , , | |
dc.identifier.volume | 40 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 616 | |
dc.identifier.endpage | 620 | |
dc.contributor.firstauthorID | 117337 | |