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dc.contributor.authorDeveli-Is, Seval
dc.contributor.authorVural, Pervin
dc.contributor.authorKalaz, Esra Betul
dc.contributor.authorEvran, Betul
dc.contributor.authorDogru-Abbasoglu, Semra
dc.contributor.authorUysal, Mujdat
dc.date.accessioned2021-03-03T17:49:52Z
dc.date.available2021-03-03T17:49:52Z
dc.date.issued2012
dc.identifier.citationKalaz E. B. , Evran B., Develi-Is S., Vural P., Dogru-Abbasoglu S., Uysal M., "Effect of Carnosine on Prooxidant-Antioxidant Balance in Several Tissues of Rats Exposed to Chronic Cold Plus Immobilization Stress", JOURNAL OF PHARMACOLOGICAL SCIENCES, cilt.120, sa.2, ss.98-104, 2012
dc.identifier.issn1347-8613
dc.identifier.otherav_4bb5423c-430a-40bf-b79c-0178b165e81f
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/54316
dc.identifier.urihttps://doi.org/10.1254/jphs.12107fp
dc.description.abstractIn this study, we investigated the effect of L-carnosine (CAR) on prooxidant antioxidant balance in several tissues of rats exposed to chronic stress. Both cold and immobilization stresses were applied to rats at the same time. In the stress group, rats were placed in restraint cages and kept in a cold room (+4 degrees C) for I h for 21 days (5 days a week). Rats were injected with CAR (250 mg/kg, i.p.) at 30 min before stress application. Malondialdehyde, diene conjugate, protein carbonyl and nitrotyrosine levels, nonenzymatic (glutathione, vitamin E, and vitamin C), and enzymatic (catalase, superoxide dismutase and glutathione peroxidase) antioxidants were determined in the liver, heart, and brain tissues. Chronic cold plus immobilization stress was observed to affect especially the prooxidant antioxidant status in the brain tissue of rats. This is the first report showing the beneficial effects of CAR on oxidative stress in the brain in rats exposed to stress.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Bilimler
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleEffect of Carnosine on Prooxidant-Antioxidant Balance in Several Tissues of Rats Exposed to Chronic Cold Plus Immobilization Stress
dc.typeMakale
dc.relation.journalJOURNAL OF PHARMACOLOGICAL SCIENCES
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume120
dc.identifier.issue2
dc.identifier.startpage98
dc.identifier.endpage104
dc.contributor.firstauthorID44602


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