dc.contributor.author | Ozkan, Gokhan | |
dc.contributor.author | Coskunpinar, Ender | |
dc.contributor.author | ORTAKOYLU, Mediha Gonenc | |
dc.contributor.author | Oltulu, Yasemin Musteri | |
dc.contributor.author | Eraltan, Ilhan Yaylim | |
dc.contributor.author | Moğulkoç, Umit | |
dc.contributor.author | Aynacı, Engin | |
dc.contributor.author | CAGLAR, Emel | |
dc.date.accessioned | 2021-03-03T17:36:34Z | |
dc.date.available | 2021-03-03T17:36:34Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Moğulkoç U., Coskunpinar E., Aynacı E., CAGLAR E., ORTAKOYLU M. G. , Ozkan G., Oltulu Y. M. , Eraltan I. Y. , "Is MMP-7 Gene Polymorphism a Possible Risk Factor for Chronic Obstructive Pulmonary Disease in Turkish Patients", GENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.16, sa.6, ss.519-523, 2012 | |
dc.identifier.issn | 1945-0265 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_4a898d18-8efa-4aab-bf59-f0dbfe533c6a | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/53558 | |
dc.identifier.uri | https://doi.org/10.1089/gtmb.2011.0271 | |
dc.description.abstract | Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that leads to fixed narrowing of small airways and alveolar wall destruction (emphysema). This study was performed to test the association between MMP-7 (rs155668818) and MMP-12 (rs56184183) polymorphisms in the MMP-7 gene and COPD risk and its severity in the Turkish population. MMP-7 and MMP-12 polymorphisms were genotyped in 85 patients with COPD and 73 healthy control subjects using real-time polymerase chain reaction analysis. There were significant differences in the distribution of MMP-7 genotypes but not in the frequencies of these alleles between COPD patients and controls (p = 0.009, p = 0.102, respectively). The MMP-7 AA genotype was found to be associated with an increased risk of COPD (p = 0.004; odds ratio: 2.576; confidence interval: 1.297-5.119). The lowest values of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC in patients with GG homozygosity were determined and these values were statistically significant compared to the control subjects (p < 0.001, p < 0.001, p < 0.001). When the present study groups were analyzed for MMP-12 polymorphism, it was found that all the subjects had wild-type genotype for this polymorphism. These findings have suggested that MMP-7 polymorphism might be associated with the risk and progression of COPD in the Turkish population. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıbbi Genetik | |
dc.subject | Tıp | |
dc.subject | GENETİK VE HAYAT | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.title | Is MMP-7 Gene Polymorphism a Possible Risk Factor for Chronic Obstructive Pulmonary Disease in Turkish Patients | |
dc.type | Makale | |
dc.relation.journal | GENETIC TESTING AND MOLECULAR BIOMARKERS | |
dc.contributor.department | Mehmet Akif Ersoy Thoracic Cardiovascular Surgery Education Research Hospital , , | |
dc.identifier.volume | 16 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 519 | |
dc.identifier.endpage | 523 | |
dc.contributor.firstauthorID | 64281 | |