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dc.contributor.authorBilgic, B
dc.contributor.authorKalayci, RİVAZE
dc.contributor.authorAhishali, Bülent
dc.contributor.authorAydin, Salih
dc.contributor.authorArican, Nadir
dc.contributor.authorKucuk, Mutlu
dc.contributor.authorUzun, Hafize
dc.contributor.authorKaya, Mehmet
dc.contributor.authorElmas, I
dc.date.accessioned2021-03-03T17:34:11Z
dc.date.available2021-03-03T17:34:11Z
dc.date.issued2005
dc.identifier.citationAhishali B., Kaya M., Kalayci R., Uzun H., Bilgic B., Arican N., Elmas I., Aydin S., Kucuk M., "Effects of lipopolysaccharide on the blood-brain barrier permeability in prolonged nitric oxide blockade-induced hypertensive rats", INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.115, sa.2, ss.151-172, 2005
dc.identifier.issn0020-7454
dc.identifier.otherav_4a56b5bf-3537-4dc8-a274-b472cf9ab503
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/53410
dc.identifier.urihttps://doi.org/10.1080/00207450590519030
dc.description.abstractThe authors investigated the effects of lipopolysaccharide (LPS) on the blood-brain harrier (BBB) integrity and the activity of astrocytes during the N-(psi)-nitro-L-arginine methyl ester (L-NAME) hypertension followed by angiotensin (ANG) II in rats. They measured the changes in the BBB permeability using the Evans blue (EB) dye and concomitantly in the levels of TNF-alpha, IL-1ss and IL-6 in serum and nitric oxide in plasma. The authors performed two tight junction-specific proteins, zondula occludens-I and occludin, and filial fibrillary acidic protein, by using inummohisto-chemical method. The serum levels of TNF-alpha. IL- 1ss, IL-6, and the plasma level of nitric oxide significantly increased in LPS-treated rats (p <. 01). The EB dye extravasation increased in cerebellum (p < .001) and diencephalon (p < .05),)of L-NAME plus ANG II-treated animals. However, LPS reduced the increased EB dye estravasation in the brain regions of L-NAME-induced hypertensive rats treated with ANG II (p <.001). In L-NAME, there was a considerable loss of staining in both zonula occludens-1 and occludin. Staining for zonula occludens-I and occludin was highly intensive in animals treated with LPS. Glial fibrillary acidic protein staining teas seen in a few astrocytes in brains of L-NAME-treated animals. However, this staining showed an increased intensity in the brain sections of animals treated with LPS. This study, indicates that. ill L-NAME hypertensive rats. ANG II leads to an increase in the ectravasation of EB dye to brain as a result of decreased activity of tight junction proteins and astrocytes, and LPS could significantly attenuate the EB dye transport to the brain through the increased activity of tight junction proteins and astrocytes.
dc.language.isoeng
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTemel Bilimler
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri
dc.titleEffects of lipopolysaccharide on the blood-brain barrier permeability in prolonged nitric oxide blockade-induced hypertensive rats
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF NEUROSCIENCE
dc.contributor.departmentİstanbul Üniversitesi , Deneysel Tıp Araştırma Enstitüsü , Laboratuvar Hayvanları Bilimi Anabilim Dalı
dc.identifier.volume115
dc.identifier.issue2
dc.identifier.startpage151
dc.identifier.endpage172
dc.contributor.firstauthorID5568


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