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dc.contributor.authorGurel, A.
dc.contributor.authorARMUTCU, FERAH
dc.contributor.authorYüncü, Mehmet
dc.contributor.authorBağcı, Cahit
dc.contributor.authorDemiryürek, Tuncay
dc.contributor.authorCeylan, Haluk
dc.date.accessioned2021-03-03T17:16:38Z
dc.date.available2021-03-03T17:16:38Z
dc.date.issued2005
dc.identifier.citationCeylan H., Yüncü M., ARMUTCU F., Gurel A., Bağcı C., Demiryürek T., "Effects of early phase of preconditioning on rat testicular ischemia", UROLOGIA INTERNATIONALIS, cilt.74, sa.2, ss.166-172, 2005
dc.identifier.issn0042-1138
dc.identifier.otherav_48e507df-0946-466b-9337-4362fd7163cf
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/52468
dc.identifier.urihttps://doi.org/10.1159/000083289
dc.description.abstractIntroduction: Brief episodes of ischemia followed by periods of reperfusion generate a powerful protective mechanism in cell, tissue or organ, which increase the resistance to further ischemic damage. This is known as ischemic preconditioning, and has not been investigated in testis. The present experiments were undertaken to determine whether early phase of ischemic preconditioning is evident in rat testis. Materials and Methods: Surgery was conducted under thiopental ( 60 mg/kg, intraperitoneal) anesthesia in male Wistar rats. Surgical procedures were performed through a midline incision. Group 1 was designed as a sham group. In group 2, which served as the ischemia group, the animals were subjected to unilateral testicular torsion by rotating the left testis 720degrees in a clockwise direction. Then, this testis was maintained in the torsion position by fixing with a silk suture to the scrotal wall for 90 min. In groups 3 and 4, 5 or 10 min ischemia followed by 10 min reperfusion was introduced, respectively, to induce single cycle ischemic preconditioning. In group 5, which served as the multiple cycle preconditioning group, 3 cycles of 10 min ischemia and 10 min reperfusion were applied prior to 90 min ischemia. Both ipsilateral and contralateral testes were removed from the rats at the end of the experimental periods, and tissue malondialdehyde (MDA), nitric oxide ( NO) levels, xanthine oxidase (XO), myeloperoxidase (MPO) and superoxide dismutase ( SOD) activities were measured. Both testes were also evaluated histologically, assessing interstitial edema, congestion, hemorrhages, rupture of tubules and Leydig cell proliferation. Results: 90 min ischemia produced a marked increase in MDA level in left testis. However, all ischemic preconditioning protocols used in this study did not show any significant modification in MDA, NO levels or XO, MPO and SOD activities. Histological grading scale was also similar in ischemia and preconditioning groups. Conclusion: These results suggest that there are no protective effects with ischemic preconditioning in rat testis as showed by biochemical analysis and histological examinations. Copyright (C) 2005 S. Karger AG, Basel.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectNefroloji
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.titleEffects of early phase of preconditioning on rat testicular ischemia
dc.typeMakale
dc.relation.journalUROLOGIA INTERNATIONALIS
dc.contributor.departmentDiğer Kurumlar , ,
dc.identifier.volume74
dc.identifier.issue2
dc.identifier.startpage166
dc.identifier.endpage172
dc.contributor.firstauthorID430628


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