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dc.contributor.authorŞENER, BİLGE
dc.contributor.authorŞENOL, FATMA SEZER
dc.contributor.authorERDOĞAN ORHAN, İLKAY
dc.contributor.authorKÜRKÇÜOĞLU, MİNE
dc.contributor.authorKhan, Mahmud Tareq Hassan
dc.contributor.authorAltintas, Ayten
dc.contributor.authorBaser, Kemal Husnu Can
dc.date.accessioned2021-03-03T16:59:24Z
dc.date.available2021-03-03T16:59:24Z
dc.date.issued2013
dc.identifier.citationŞENOL F. S. , ERDOĞAN ORHAN İ., KÜRKÇÜOĞLU M., Khan M. T. H. , Altintas A., ŞENER B., Baser K. H. C. , "A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.)", FOOD RESEARCH INTERNATIONAL, cilt.53, sa.1, ss.502-509, 2013
dc.identifier.issn0963-9969
dc.identifier.othervv_1032021
dc.identifier.otherav_47521b4a-2093-4c4b-86bd-1256af5dfd91
dc.identifier.urihttp://hdl.handle.net/20.500.12627/51508
dc.identifier.urihttps://doi.org/10.1016/j.foodres.2013.05.031
dc.description.abstractIn the current study, neuroprotective effect of the essential oil and aromatic waters of rose was investigated by in vitro and in silico methods. The samples were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Since oxidative damage is associated with neurodegeneration, antioxidant activity of the samples was determined by DPPH radical scavenging, metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. Their chemical composition was elucidated by GC-MS. Anti-cholinesterase effects of the main components (citronellol, geraniol, nerol, and phenylethyl alcohol) were also examined. The rose oil showed a noteworthy inhibition against AChE (60.86 +/- 1.99%) and BChE (51.08 +/- 1.70%) at 1000 mu g/mL and low activity in DPPH radical scavenging and FRAP tests. Phenylethyl alcohol exerted higher cholinesterase inhibition than other components and applied further to molecular docking simulations. Docking and binding energies supporting experimental results show that the compound is more selective towards BChE than AChE. (C) 2013 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectTarım Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectGıda Mühendisliği
dc.subjectMühendislik ve Teknoloji
dc.subjectGIDA BİLİMİ VE TEKNOLOJİSİ
dc.titleA mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.)
dc.typeMakale
dc.relation.journalFOOD RESEARCH INTERNATIONAL
dc.contributor.departmentGazi Üniversitesi , Eczacılık Fakültesi , Farmakognozi Anabilim Dalı
dc.identifier.volume53
dc.identifier.issue1
dc.identifier.startpage502
dc.identifier.endpage509
dc.contributor.firstauthorID210370


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