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The antihistamine fexofenadine does not affect I-Kr currents in a case report of drug-induced cardiac arrhythmia

dc.contributor.authorWollnik, B
dc.contributor.authorMaier, P
dc.contributor.authorFicker, E
dc.contributor.authorSteinmeyer, K
dc.contributor.authorBusch, AE
dc.contributor.authorScherer, CR
dc.contributor.authorLerche, C
dc.contributor.authorDecher, N
dc.contributor.authorDennis, AT
dc.date.accessioned2021-03-03T16:56:25Z
dc.date.available2021-03-03T16:56:25Z
dc.date.issued2002
dc.identifier.citationScherer C., Lerche C., Decher N., Dennis A., Maier P., Ficker E., Busch A., Wollnik B., Steinmeyer K., "The antihistamine fexofenadine does not affect I-Kr currents in a case report of drug-induced cardiac arrhythmia", BRITISH JOURNAL OF PHARMACOLOGY, cilt.137, sa.6, ss.892-900, 2002
dc.identifier.issn0007-1188
dc.identifier.othervv_1032021
dc.identifier.otherav_471368e8-7373-475a-b5df-d5108fabeb56
dc.identifier.urihttp://hdl.handle.net/20.500.12627/51343
dc.identifier.urihttps://doi.org/10.1038/sj.bjp.0704873
dc.description.abstract1 The human HERG gene encodes the cardiac repolarizing K+ current I-Kr and is genetically inactivated in inherited long QT syndrome 2 (LQTS2). The antihistamine terfenadine blocks HERG channels, and can cause QT prolongation and torsades de pointes, whereas its carboxylate fexofenadine lacks HERG blocking activity.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.titleThe antihistamine fexofenadine does not affect I-Kr currents in a case report of drug-induced cardiac arrhythmia
dc.typeMakale
dc.relation.journalBRITISH JOURNAL OF PHARMACOLOGY
dc.contributor.department, ,
dc.identifier.volume137
dc.identifier.issue6
dc.identifier.startpage892
dc.identifier.endpage900
dc.contributor.firstauthorID166417


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